{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:05:25Z","timestamp":1778177125930,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Magnetic resonance imaging (MRI) is a powerful, noninvasive tool to study fetal lung volumes after 18\u2009weeks of gestation <jats:italic>in vivo<\/jats:italic>. In neonates with congenital heart disease (CHD), proper lung function is essential for postnatal survival. Antenatal detection of abnormal pulmonary development may help to optimize prenatal and perinatal management of at\u2010risk fetuses. We aimed to investigate lung volumes in fetuses with prenatally diagnosed heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional, retrospective study of 105 consecutive singleton pregnancies with CHD and a control, non\u2010CHD group (<jats:italic>n<\/jats:italic>\u2009=\u2009115), that underwent fetal MRI was performed. The heart defects detected were divided into four groups. Lung volumes of fetuses with heart disease were compared with control, non\u2010CHD fetuses. In addition, <jats:italic>z<\/jats:italic>\u2010scores of lung volumes were calculated for the CHD group (normal range <jats:italic>z<\/jats:italic>\u2010scores from \u22122\u2013+2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As a group, fetuses with CHD have significantly smaller lung volumes compared with control fetuses when corrected by gestational age (GA) (<jats:italic>p<\/jats:italic>\u2009=\u20090.049). Of the 105 CHD fetuses studied, 18 had lung volumes with a <jats:italic>z<\/jats:italic>\u2010score\u2009&lt;\u2009\u22122. Fetuses with different types of CHD showed similar lung volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that postpartum pulmonary symptoms and outcome in neonates with congenital heart disease may be attributed to the cardiac disease itself and in part to smaller lung volumes. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4308","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T14:02:49Z","timestamp":1387807369000},"page":"273-278","source":"Crossref","is-referenced-by-count":12,"title":["Fetal cardiac disease and fetal lung volume: an <i>in utero<\/i> MRI investigation"],"prefix":"10.1002","volume":"34","author":[{"given":"Elisabeth","family":"Mlczoch","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Pediatric Heart Center Vienna, Department of Pediatrics and Adolescent Medicine Medical University of Vienna  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