{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:01:11Z","timestamp":1790650871286,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to determine the reproducibility, the inter\u2010hemispheric difference and the reference apparent diffusion coefficient (ADC) values of the fetal brain according to gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>One hundred and one normal fetal brain (29.4\u201338.4\u2009weeks) were analysed with diffusion\u2010weighted MR imaging. ADC was measured in frontal white matter (FWM), occipital white matter (OWM), centrum semi\u2010ovale (CSO), basal ganglia (BG), cerebellar hemisphere (CBM) and pons. ADC ratios (fronto\u2010occipital, fronto\u2010cerebellar and occipito\u2010cerebellar) were calculated. Inter\u2010observer reproducibility was assessed on 27 studies, using intra\u2010class correlation coefficient and Bland\u2013Altman plot. Inter\u2010hemispheric difference was evaluated with Bland\u2013Altman plot. Gestation\u2010specific reference intervals were estimated for each brain region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inter\u2010observer bias was near zero. Limits of agreement (LOA) were clinically acceptable (\u22120.17; 0.20 to \u22120.38; 0.31\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/s) for all brain regions except for CSO and pons. Inter\u2010hemispheric bias was near zero. Smallest LOA were for FWM (\u00b10.09\u2009mm<jats:sup>2<\/jats:sup>\/s) and BG (\u00b10.019\u2009mm<jats:sup>2<\/jats:sup>\/s). ADC values decreased, whereas ADC ratio increased with gestational age, reflecting normal maturation. Fronto\u2010occipital, fronto\u2010cerebellar and occipito\u2010cerebellar ratios were consistently above 0.8, 1 and 1, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The fetal brain regions with the highest reproducibility and smallest inter\u2010hemispheric differences are the frontal, occipital, cerebellar white matter and BG. ADC ratio could be useful to assess differential temporo\u2010spatial maturation. \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4309","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T03:21:58Z","timestamp":1387855318000},"page":"357-366","source":"Crossref","is-referenced-by-count":20,"title":["Apparent diffusion coefficient measurements of the fetal brain during the third trimester of pregnancy: how reliable are they in clinical practice?"],"prefix":"10.1002","volume":"34","author":[{"given":"Agn\u00e8s","family":"Sartor","sequence":"first","affiliation":[{"name":"Service de Gyn\u00e9cologie-Obst\u00e9trique, H\u00f4pital Robert Debr\u00e9 AP-HP, Inserm UMR 676, Universit\u00e9 Paris Diderot \u2013 Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Arthurs","sequence":"additional","affiliation":[{"name":"Service d'Imagerie P\u00e9diatrique et 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