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Peripartum therapies, such as prenatal maternal corticosteroids and magnesium sulphate, can prevent some of the adverse neonatal outcomes, but there is currently no treatment for poor placentation itself. Instead, management relies on identifying the consequences of poor placentation in the mother and fetus, with iatrogenic preterm delivery to minimise mortality and morbidity. Several promising therapies are currently under development to treat poor placentation, to improve fetal growth, and to prevent adverse neonatal outcomes. Interventions such as maternal nitric oxide donors, sildenafil citrate, vascular endothelial growth factor gene therapy, hydrogen sulphide donors, and statins address the underlying pathology, while maternal melatonin administration may provide fetal neuroprotection. In the future, these may provide a range of synergistic therapies for pre\u2010eclampsia and fetal growth restriction, depending on the severity and gestation of onset. \u00a9 2014 The Authors. <jats:italic>Prenatal Diagnosis<\/jats:italic> published by John Wiley &amp; Sons Ltd.<\/jats:p>","DOI":"10.1002\/pd.4401","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T11:20:42Z","timestamp":1399029642000},"page":"677-684","source":"Crossref","is-referenced-by-count":45,"title":["Treatment of poor placentation and the prevention of associated adverse outcomes \u2013 what does the future hold?"],"prefix":"10.1002","volume":"34","author":[{"given":"R. N.","family":"Spencer","sequence":"first","affiliation":[{"name":"Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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