{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:23:13Z","timestamp":1759580593533,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005797","name":"Erasmus Trustfonds","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005797","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010429","name":"Erasmus Vriendenfonds","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010429","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003142","name":"Fonds NutsOhra","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003142","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Meindert de Hoop foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although second\u2010trimester and third\u2010trimester reference curves for human fetal hand growth allow for identification of several genetic syndromes, little is known about first\u2010trimester hand growth. We investigated first\u2010trimester hand growth in euploid and aneuploid fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Between 9 and 12\u2009weeks' gestational age (GA), wrist width, hand width, hand length, and hand index were measured in three\u2010dimensional (3D) ultrasound datasets of 112 euploid and 65 aneuploid pregnancies. We constructed reference curves for these measurements in euploid pregnancies and calculated <jats:italic>z<\/jats:italic>\u2010scores for measurements in aneuploid pregnancies. Reproducibility was established in a subset of 20 datasets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While wrist width, hand width, and hand length increased with gestational age, hand index decreased. Intraobserver and interobserver intraclass correlation coefficient values were &gt;0.97.<\/jats:p><jats:p>In trisomy 21 cases, wider wrists and hands were observed compared with euploid pregnancies (mean <jats:italic>z<\/jats:italic>\u2010scores 1.06, SD 2.04, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and 1.16, SD 1.30, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). Trisomy 18 cases showed narrower and shorter hands (mean <jats:italic>z<\/jats:italic>\u2010scores \u22120.74, SD 1.20, <jats:italic>p<\/jats:italic>\u2009=\u20090.009 and \u22120.97, SD 0.86, <jats:italic>p<\/jats:italic>\u2009=\u20090.005, respectively). In trisomy 13 cases, no differences were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reference values are available for first\u2010trimester studies on human hand development. First\u2010trimester hand measurements in trisomies 21 and 18 differ significantly from those in euploid pregnancies and may be useful for early identification of abnormal development. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4404","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T22:54:36Z","timestamp":1399762476000},"page":"961-969","source":"Crossref","is-referenced-by-count":5,"title":["First\u2010trimester hand measurements in euploid and aneuploid human fetuses using virtual reality"],"prefix":"10.1002","volume":"34","author":[{"given":"Leonie","family":"Baken","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine Erasmus MC University Medical Centre Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Benoit","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Princess Grace Hospital  Monaco Monaco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton H. 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