{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:20:42Z","timestamp":1773289242869,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T00:00:00Z","timestamp":1402444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Diagnostic Technologies Limited"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the predictive accuracy of second\u2010trimester ultrasound parameters, maternal characteristics, and sequential Doppler changes between first and second trimesters for the prediction of small\u2010for\u2010gestational\u2010age (SGA) infants (birth weight\u2009&lt;\u200910th percentile).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective study of singleton pregnancies enrolled in the first trimester with subsequent second\u2010trimester follow\u2010up. Maternal characteristics, uterine artery (UtA) pulsatility index (PI), fetal biometry, and umbilical artery (UA)\u2010PI were ascertained. UtA and UA\u2010PI change from first to second trimester was calculated (\u0394UtA\u2010PI and \u0394UA\u2010PI). These parameters were tested for their ability to predict delivery of an SGA infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1982 women, 172 delivered an SGA neonate. African\u2010American ethnicity, nulliparity, tobacco use, and low abdominal circumference (AC) <jats:italic>z<\/jats:italic>\u2010score were independent predictors of SGA. No difference was found in the magnitude of \u0394UtA\u2010PI and \u0394UA\u2010PI between SGA and no\u2010SGA. Receiver\u2013operating characteristics curve analysis yielded an area under the curve of 0.700 for AC <jats:italic>z<\/jats:italic>\u2010score. The combination of low AC and bilateral notching had high specificity (99%) but low sensitivity (7%) for SGA prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A small second\u2010trimester fetal AC is a specific marker for SGA when found with bilateral UtA notching. Only a small proportion is predicted by the factors studied, suggesting a small contributory role or later evolution of SGA. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4418","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T08:52:40Z","timestamp":1400921560000},"page":"1037-1043","source":"Crossref","is-referenced-by-count":16,"title":["Second\u2010trimester prediction of delivery of a small\u2010for\u2010gestational\u2010age neonate: integrating sequential Doppler information, fetal biometry, and maternal characteristics"],"prefix":"10.1002","volume":"34","author":[{"given":"Viola","family":"Seravalli","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences University of Maryland School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana 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