{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:38:13Z","timestamp":1791437893957,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This article is a systematic review of the literature to establish the detection rate and false\u2010positive rate of the combined test for the screening of trisomy 21 in twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We conducted a literature search (MEDLINE, EMBASE and ScienceDirect and Cochrane) to identify studies between 1995 and 2013 that provided data on the combined test in twins. Selected studies included data on maternal age, number of fetuses affected by Down syndrome, test strategy, sensitivity and specificity of the test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The combined test in twins had a pooled sensitivity of 0.893 [95% confidence interval (CI) 0.797\u20130.947] and a pooled specificity of 0.946 (95% CI 0.933\u20130.957). The performance of the test was good (summary receiver operating characteristic area under the curve: 0.817). In dichorionic twins, sensitivity and specificity were 0.862 (95% CI 0.728\u20130.936) and 0.952 (95% CI 0.942\u20130.96), respectively. In monochorionic twins, the sensitivity and specificity were 0.874% (95% CI 0.526\u20130.977) and 0.954% (95% CI 0.943\u20130.963), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this meta\u2010analysis show that the accumulative evidence on the performance of the combined test in twin pregnancies is good. Nowadays, it seems to be the best first\u2010trimester screening test available for twin pregnancies. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4431","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T05:04:48Z","timestamp":1402463088000},"page":"1077-1083","source":"Crossref","is-referenced-by-count":76,"title":["Systematic review of screening for trisomy 21 in twin pregnancies in first trimester combining nuchal translucency and biochemical markers: a meta\u2010analysis"],"prefix":"10.1002","volume":"34","author":[{"given":"Pilar","family":"Prats","sequence":"first","affiliation":[{"name":"Fetal Medicine Service, Department of Obstetrics, Gynecology and Reproductive Medicine Hospital Universitari Quir\u00f3n Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Fetal Medicine Service, Department of Obstetrics, Gynecology and Reproductive Medicine Hospital Universitari Quir\u00f3n Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina","family":"Comas","sequence":"additional","affiliation":[{"name":"Fetal Medicine Service, Department of Obstetrics, Gynecology and Reproductive Medicine Hospital Universitari Quir\u00f3n Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bienvenido","family":"Puerto","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetr\u00edcia I Neonatologia Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Births: final data for 2004","volume":"55","author":"Martin JA","year":"2006","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12574"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8845"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00881-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00808.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.288"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02246.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025273"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1860"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6412"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802430842"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2902"},{"key":"e_1_2_6_14_1","first-page":"99","article-title":"Screening for trisomy 21 in twin pregnancies by maternal age and fetal nuchal translucency thickness at 10\u201314 weeks of gestation","volume":"103","author":"Sebire NJ","year":"1996","journal-title":"Br J Obstet Gyncecol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200002)20:2<91::AID-PD759>3.0.CO;2-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02222.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.037"},{"key":"e_1_2_6_18_1","unstructured":"National Institute for Health and Clinical Excellence.Multiple Pregnancy: The Management of Twin and Triplet Pregnancies in the Antenatal Period. 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