{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:39:05Z","timestamp":1788871145075,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Union health programme","award":["2006103"],"award-info":[{"award-number":["2006103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study is to describe the prenatal diagnosis and epidemiology of multicystic kidney dysplasia (MCKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study is based on routinely collected data from a European database of major congenital anomalies including 13 registries with cases born in 1997\u20132006 and covering 1\u2009458\u2009552 births.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 601 MCKD cases giving an overall prevalence of 4.12 per 10\u2009000 births with regional variation. In live births, 87% of cases had an isolated renal anomaly and 13% had associated major nonrenal anomalies (chromosomal, syndrome or other major anomalies). For the cases with isolated renal anomalies, 51\/386 (11%) and 7\/386 (2%) choose to terminate the pregnancy or resulted in an intrauterine fetal death, respectively. The prenatal detection rate was 88% in both unilateral and bilateral cases. Birth outcome differed with 92% of unilateral MCKD cases being liveborn compared with 33% of bilateral MCKD cases. For unilateral MCKD cases, 84% had an isolated renal anomaly compared with 51% of bilateral MCKD cases (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cases with unilateral MCKD are mainly liveborn, and only 16% have associated major malformations or a syndrome. Cases with bilateral MCKD are often associated with nonrenal major congenital anomalies or part of a syndrome, and only one third of bilateral MCKD cases in this study were liveborn. Prenatal detection rate of MCKD was high for both unilateral and bilateral cases. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.4433","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T05:28:47Z","timestamp":1402464527000},"page":"1093-1098","source":"Crossref","is-referenced-by-count":23,"title":["Prenatal diagnosis and epidemiology of multicystic kidney dysplasia in Europe"],"prefix":"10.1002","volume":"34","author":[{"given":"Louise","family":"Winding","sequence":"first","affiliation":[{"name":"Paediatric Department Hospital Lillebaelt  Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Loane","sequence":"additional","affiliation":[{"name":"University of Ulster  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Wellesley","sequence":"additional","affiliation":[{"name":"Princess Anne Hospital  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claude","family":"Addor","sequence":"additional","affiliation":[{"name":"Registry of Vaud Switzerland, Division of Medical Genetics CHUV  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larraitz","family":"Arriola","sequence":"additional","affiliation":[{"name":"Public Health Division of Gipuzkoa, Instituto BIO\u2010Donostia, Basque Government CIBER Epidemiolog\u00eda y Salud P\u00fablica \u2013 CIBERESP  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian K.","family":"Bakker","sequence":"additional","affiliation":[{"name":"EUROCAT Northern Netherlands, Department of Genetics University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Bianchi","sequence":"additional","affiliation":[{"name":"CNR Institute of Clinical Physiology and G. Monasterio Tuscany Foundation  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Calzolari","sequence":"additional","affiliation":[{"name":"Registro IMER \u2013 IMER Registry (Emila Romagna Registry of Birth Defects) Azienda Ospedaliero\u2010Universitaria di Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Gatt","sequence":"additional","affiliation":[{"name":"Malta Congenital Anomalies Register Directorate for Health Information and Research  Valletta Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Haeusler","sequence":"additional","affiliation":[{"name":"Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Lelong","sequence":"additional","affiliation":[{"name":"INSERM, U953 Universite Paris\u20106  Paris 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