{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:36:06Z","timestamp":1780731366211,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the feasibility of incorporating two\u2010dimensional ultrasound measurements of nasal bone length (NBL) and prenasal thickness (PT) into the second\u2010trimester anomaly scan and to determine whether the NBL\u2009:\u2009PT ratio could help in differentiating euploid and Down syndrome fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Two\u2010dimensional measurements of NBL and PT were obtained from the midsagittal plane of the fetal head at 14\u201328\u2009weeks of gestation in a Caucasian population at risk for aneuploidy. The screening performances of NBL, PT, and the ratios NBL\u2009:\u2009PT and PT\u2009:\u2009NBL were analyzed in euploid (<jats:italic>n<\/jats:italic>\u2009=\u20091330) and Down syndrome (<jats:italic>n<\/jats:italic>\u2009=\u200933) fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nasal bone length and PT alone showed strong correlations with Down syndrome (sensitivity: 76% at 1.88% and 2.35% false positive rate, respectively). However, the NBL\u2009:\u2009PT ratio showed an even stronger correlation with Down syndrome (false positive rate: 0.9%, sensitivity: 97%). The mean NBL\u2009:\u2009PT ratio showed a gradual increase from 1.48 to 1.79 (a 21.2% increase) between 14 and 28\u2009weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two\u2010dimensional ultrasound measurements of NBL and PT, particularly the NBL\u2009:\u2009PT ratio, are highly sensitive markers for Down syndrome fetuses. \u00a9 2014 The Authors. <jats:italic>Prenatal Diagnosis<\/jats:italic> published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4442","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T23:38:45Z","timestamp":1403739525000},"page":"1139-1145","source":"Crossref","is-referenced-by-count":14,"title":["Nasal bone length:\u2009prenasal thickness ratio: a strong 2D ultrasound marker for Down syndrome"],"prefix":"10.1002","volume":"34","author":[{"given":"Andrea","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"MEDISONO Fetal and Adult Health Research Center  Szeged Hungary"},{"name":"Department of Medical Genetics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1roly","family":"Szili","sequence":"additional","affiliation":[{"name":"MEDISONO Fetal and Adult Health Research Center  Szeged Hungary"},{"name":"Department of Medical Genetics University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos Tam\u00e1s","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"MEDISONO Fetal and Adult Health Research Center  Szeged Hungary"},{"name":"Department of Obstetrics and Gynecology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Sikovanyecz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ra","family":"Isaszegi","sequence":"additional","affiliation":[{"name":"MEDISONO Fetal and Adult Health Research Center  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"MEDISONO Fetal and Adult Health Research Center  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9280-0192","authenticated-orcid":false,"given":"J\u00e1nos","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"MEDISONO Fetal and Adult Health Research Center  Szeged Hungary"},{"name":"Department of Medical Genetics University of Szeged  Szeged 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