{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T21:31:57Z","timestamp":1764019917718},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T00:00:00Z","timestamp":1408924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Echocardiography screening in anti\u2010SSA antibody exposed fetuses is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The aim of this study is to evaluate utility of fetal echocardiography in anti\u2010SSA exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Echocardiograms performed over 9\u2009years for maternal anti\u2010SSA exposure were reviewed for atrioventricular (AV) block, cardiomyopathy, arrhythmias, effusion, valve abnormalities, or other abnormalities identified by the echocardiographer. Fetuses with AV block referred to our institution and subsequently found to be anti\u2010SSA exposed were also identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Six hundred thirty six echocardiograms were performed on 140 fetuses (Cohort 1) of 134 women screened for maternal anti\u2010SSA +\/\u2212 anti\u2010SSB antibodies. No fetuses developed second or third\u2010degree AV block or cardiomyopathy (odds ratio 0.1, CI 0.0051 to 1.9410, <jats:italic>p<\/jats:italic>\u2009=\u20090.13). Dexamethasone was administered to three fetuses for sinus bradycardia, echogenicity near AV node, and ventricular systolic dysfunction with valve regurgitation; all normalized. Screening echocardiograms identified: sinus bradycardia (<jats:italic>n<\/jats:italic>\u2009=\u20091), PR prolongation (<jats:italic>n<\/jats:italic>\u2009=\u20095), premature atrial contractions (<jats:italic>n<\/jats:italic>\u2009=\u20093), valve regurgitation (<jats:italic>n<\/jats:italic>\u2009=\u200924), echogenic myocardium (<jats:italic>n<\/jats:italic>\u2009=\u20094), and pericardial effusion (<jats:italic>n<\/jats:italic>\u2009=\u20091). Isolated tricuspid regurgitation and first\u2010degree AV block did not progress. Nine cases of SSA\u2010mediated AV block (Cohort 2) were referred after heart block developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Serial fetal echocardiography in anti\u2010SSA exposed fetuses did not detect AV block. In rare cases, dexamethasone treatment may have affected disease course. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4454","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T08:28:56Z","timestamp":1404376136000},"page":"1207-1212","source":"Crossref","is-referenced-by-count":24,"title":["Outcomes of fetal echocardiographic surveillance in anti\u2010SSA exposed fetuses at a large fetal cardiology center"],"prefix":"10.1002","volume":"34","author":[{"given":"Anita","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Children's National Heart Institute Children's National Medical Center  111 Michigan Ave, NW Washington DC 20010 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawna","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Children's National Heart Institute Children's National Medical Center  111 Michigan Ave, 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