{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:39:43Z","timestamp":1790177983745,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270705"],"award-info":[{"award-number":["81270705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this article is to investigate the prevalence, clinical presentation, prenatal management, and prognosis of mirror syndrome associated with twin\u2013twin transfusion syndrome (TTTS) treated by amnioreduction or selective fetocide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study of twin pregnancies with TTTS was conducted. The prevalence of mirror syndrome, defined as severe maternal edema related to fetal hydrops and placental edema, was calculated for TTTS, and data on clinical characteristics, treatment, and outcomes of the patients were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed mirror syndrome in 4.85% (5\/103) of pregnancies with TTTS and 26.32% (5\/19) of pregnancies with TTTS Stage IV. Most cases (4\/5) of mirror syndrome associated with TTTS were diagnosed before 24\u2009weeks of gestation. The patients manifested edema, anemia, hemodilution, and hypoproteinemia (5\/5); proteinuria (4\/5); complicated postpartum hemorrhage (4\/5); and pulmonary edema and congestive heart failure (2\/5). Maternal hemoglobin, hematocrit, and plasma protein dropped after amnioreduction. The perinatal survival rate at 28\u2009days was 28.57% (2\/7), and only one infant born after selective feticide survived beyond 18\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TTTS carries a high risk of mirror syndrome, a disease with significant materno\u2010fetal mortality and morbidity. Amnioreduction alone or with selective feticide in mirror syndrome may transiently aggravate anemia and hemodilution and lead to severe maternal complications. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4458","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T10:38:01Z","timestamp":1404902281000},"page":"1213-1218","source":"Crossref","is-referenced-by-count":7,"title":["Prenatal management and outcomes in mirror syndrome associated with twin\u2013twin transfusion syndrome"],"prefix":"10.1002","volume":"34","author":[{"given":"Hanjing","family":"Chai","sequence":"first","affiliation":[{"name":"Fetal Medicine Center, Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Fang","sequence":"additional","affiliation":[{"name":"Fetal Medicine Center, Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Fetal Medicine Center, Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fetal Medicine Center, Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-0767","authenticated-orcid":false,"given":"Yanmin","family":"Luo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Center, Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.1_Spec_No.66"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000305096"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8802"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1342"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2128"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12286"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198609000-00009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3760\/cma.j.issn.0366-6999.2010.05.008","article-title":"Fetal reduction by bipolar cord coagulation in managing complicated monochorionic multiple pregnancies: preliminary experience in china","volume":"123","author":"He ZM","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.02.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.10.880"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2818"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.02.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2461"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600922677"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000178532"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.02.016"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199705000-00023"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(199809\/10)7:5<227::AID-MFM3>3.0.CO;2-I"},{"key":"e_1_2_6_21_1","first-page":"360","article-title":"Reversal of Ballantyne syndrome by selective second\u2010trimester fetal termination. A case report","volume":"45","author":"Heyborne KD","year":"2000","journal-title":"J Reprod Med"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2003.12.011"},{"key":"e_1_2_6_23_1","first-page":"175","article-title":"Clinical study of 12 cases with obstetric mirror syndrome","volume":"47","author":"Wu LL","year":"2012","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.733765"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.79.6.576"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970151309"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10136"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.02.016"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086835"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080163"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07055.x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4458","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:03:47Z","timestamp":1716984227000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,23]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/pd.4458"],"URL":"https:\/\/doi.org\/10.1002\/pd.4458","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,23]]}}}