{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:55:16Z","timestamp":1790088916694,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate fetal lung growth rate for isolated left\u2010sided congenital diaphragmatic hernia (CDH) using serial magnetic resonance imaging (MRI)\u2010based volumetric measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Early and late gestational (22\u201330 and &gt;30\u2009weeks' gestation) lung volumetry was obtained by fetal MRI in 47 cases of isolated left\u2010sided CDH. At both of these time points, lung volume indices, including total lung volume (TLV), observed to expected TLV (o\/e TLV), and percentage of predicted lung volume (PPLV) as well as their change rates (\u0394) and relative \u0394 during gestation were calculated and analyzed in regard to their capacity to predict neonatal survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TLV, o\/e TLV, and PPLV had various changes during gestation. Late TLV, early and late o\/e TLV, and late PPLV were predictive of neonatal survival. Non\u2010survivors had lower \u0394TLV and more negative relative \u0394PPLV than survivors (1.18 vs 1.85\u2009mL\/week, <jats:italic>P<\/jats:italic>\u2009=\u20090.004 and \u22124.15%\/week vs \u22121.95%\/week, <jats:italic>P<\/jats:italic>\u2009=\u20090.002, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The severity of pulmonary hypoplasia is dynamic and can worsen in the third trimester. MRI lung volumetry repeated in late gestation can provide additional information on individual lung growth that may facilitate prenatal counseling and focus perinatal management. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4510","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T11:22:04Z","timestamp":1412853724000},"page":"160-166","source":"Crossref","is-referenced-by-count":38,"title":["Fetal lung growth represented by longitudinal changes in MRI\u2010derived fetal lung volume parameters predicts survival in isolated left\u2010sided congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8373-8355","authenticated-orcid":false,"given":"Alan","family":"Coleman","sequence":"first","affiliation":[{"name":"Cincinnati Fetal Center Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Division of Pediatric, General and Thoracic 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Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Division of Pediatric, General and Thoracic Surgery Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Kline\u2010Fath","sequence":"additional","affiliation":[{"name":"Cincinnati Fetal Center Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Division of Pediatric Radiology Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kingma","sequence":"additional","affiliation":[{"name":"Cincinnati Fetal Center Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Division of Neonatology Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Haberman","sequence":"additional","affiliation":[{"name":"Division of Neonatology Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foong\u2010Yen","family":"Lim","sequence":"additional","affiliation":[{"name":"Cincinnati Fetal Center Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Division of Maternal\u2013Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital  Bangkok 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