{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:47:33Z","timestamp":1790718453043,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Apert syndrome is characterized by craniosynostosis and complex hand and foot syndactyly, and an increased risk of brain, palate, heart, and visceral malformations, and intellectual disability. This study aims to describe the structural brain abnormalities detected by dedicated neuroimaging of fetuses with Apert syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of ultrasound and magnetic resonance imaging brain imaging obtained in six fetuses with a diagnosis of Apert syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five fetuses had attenuation of the septal leaflets, and two had corpus callosum dysgenesis. All six had temporal lobe expansion and overconvolution and temporal lobe clefts. The temporal lobe abnormalities preceded the development of cranial deformity in two fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overexpansion and overconvolution of the temporal lobe is evident antenatally and is particularly conspicuous in the fetus when the normal brain is still relatively smooth (approximately 24 to 28\u2009weeks of gestation). \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4515","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T11:27:31Z","timestamp":1412854051000},"page":"179-182","source":"Crossref","is-referenced-by-count":30,"title":["Apert syndrome: temporal lobe abnormalities on fetal brain imaging"],"prefix":"10.1002","volume":"35","author":[{"given":"Zornitza","family":"Stark","sequence":"first","affiliation":[{"name":"Victorian Clinical Genetics Services Murdoch Children's Research Institute  Melbourne Australia"},{"name":"Fetal Medicine Unit Royal Women's Hospital  Melbourne Australia"},{"name":"Maternal Fetal Medicine, Sunshine Hospital Western Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"McGillivray","sequence":"additional","affiliation":[{"name":"Victorian Clinical Genetics Services Murdoch Children's Research Institute  Melbourne Australia"},{"name":"Fetal Medicine Unit Royal Women's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Sampson","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Royal Women's Hospital  Melbourne Australia"},{"name":"Pauline Gandell Women's Imaging Centre The Royal Women's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Palma\u2010Dias","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Royal Women's Hospital  Melbourne Australia"},{"name":"Pauline Gandell Women's Imaging Centre The Royal Women's Hospital  Melbourne Australia"},{"name":"Pregnancy Research Centre, Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Edwards","sequence":"additional","affiliation":[{"name":"Fetal Diagnostic Unit Monash Medical Centre  Melbourne Australia"},{"name":"The Ritchie Centre Monash Institute of Medical Research  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Said","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Royal Women's Hospital  Melbourne Australia"},{"name":"Maternal Fetal Medicine, Sunshine Hospital Western Health  Melbourne Australia"},{"name":"NorthWest Academic Centre The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Whiteley","sequence":"additional","affiliation":[{"name":"Department of Radiology Monash Medical Centre  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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