{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:49:36Z","timestamp":1754261376562},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the State Natural Sciences Foundation of China","award":["no. 81271593"],"award-info":[{"award-number":["no. 81271593"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to evaluate the prenatal diagnosis of ventricular non\u2010compaction cardiomyopathy (NCCM) and to report the pathologic features and the characteristic myocardial ultrastructure of fetal NCCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We examined nine cases of fetal NCCM by prenatal echocardiography from 2004 to 2013. These cases were evaluated with respect to prenatal diagnosis, outcomes, pathology, and characteristics of the myocardial ultrastructure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Trabeculated myocardium and non\u2010compaction\/compaction ratio (N\/C ratio) \u22652.0 is the echocardiographic feature that allowed diagnosis. Among the nine fetuses with a prenatal diagnosis of NCCM, six were diagnosed with left ventricular non\u2010compaction (LVNC), two with non\u2010compaction of both ventricles (biventricular NCCM), and one with right ventricular non\u2010compaction. Among the nine fetuses, the LVNC diagnosis was confirmed by postnatal echocardiography in 2; the other patients chose to terminate their pregnancies, and those cases were confirmed at autopsy. Muscle biopsies were performed on three of the aborted fetuses, and abnormal mitochondria, sarcomeres, and myocardial fibers were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010compaction can be identified in the fetus. Fetal non\u2010compaction most often involves the left ventricle, but can involve the right ventricle or both ventricles. The myocardial ultrastructure of fetal ventricular non\u2010compaction has certain unique characteristics regarding the maturation of the mitochondria, sarcomeres, and myocardial fibers. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4523","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T22:49:07Z","timestamp":1414190947000},"page":"221-227","source":"Crossref","is-referenced-by-count":12,"title":["Ventricular non\u2010compaction cardiomyopathy: prenatal diagnosis and pathology"],"prefix":"10.1002","volume":"35","author":[{"given":"Leiqi","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Ultrasonography, The Second Xiangya Hospital Central South University  No.139 Middle Renmin Road Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qichang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, The Second Xiangya Hospital Central South University  No.139 Middle Renmin Road Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography First Affiliated Hospital of University of South China  Chuanshan Road Hengyang Hunan 421001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, The Second Xiangya Hospital Central South University  No.139 Middle Renmin Road Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danming","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, The Second Xiangya Hospital Central South University  No.139 Middle Renmin Road Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, The Second Xiangya Hospital Central South University  No.139 Middle Renmin Road Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"issue":"12","key":"e_1_2_6_2_1","first-page":"206","article-title":"Isolated non\u2010compaction cardiomyopathy","volume":"107","author":"Engberding R","year":"2010","journal-title":"Dtsch Arztebl 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