{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:22:09Z","timestamp":1778923329948,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the results of first\u2010trimester combined screening for Down syndrome in women with chronic renal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifty\u2010five pregnant women with renal disease were compared with 110 patients matched for maternal age, maternal weight, smoking status, and gestational age. Maternal renal function was assayed at the time of the combined screening, and renal insufficiency was defined by serum creatinine &gt;90\u2009\u00b5mol\/L and renal clearance &lt;80\u2009mL\/min. We defined three groups: kidney disease and normal renal function (group 1), kidney disease and renal insufficiency (group 2), and a control group (group 3). The values of nuchal translucency, pregnancy\u2010associated plasma protein A, human <jats:italic>\u03b2<\/jats:italic>\u2010chorionic gonadotrophin (hCG<jats:italic>\u03b2<\/jats:italic>), and false\u2010positive rates for Down syndrome screening were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 39 (71%) and 16 (29%) cases in groups 1 and 2, respectively. Nuchal translucency and multiple of the median (MoM) pregnancy\u2010associated plasma protein A were similar in the three groups. However, MoM hCG<jats:italic>\u03b2<\/jats:italic> levels were higher in group 2 than in groups 1 and 3 (5.37 vs 1.1 vs 0.98 MoM, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001). The resulting screen\u2010positive rate was also higher in group 2 than in groups 1 and 3 (43.7% vs 10.2% vs 5.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Trisomy 21 first\u2010trimester screening using hCG<jats:italic>\u03b2<\/jats:italic> is not suitable in the case of maternal renal failure. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4528","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T06:15:33Z","timestamp":1415945733000},"page":"244-248","source":"Crossref","is-referenced-by-count":16,"title":["First\u2010trimester combined screening for trisomy 21 in women with renal disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Morgane","family":"Valentin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Maternal\u2010Fetal Medicine Necker Enfants Malades Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Prenatal Biochemistry Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Paule","family":"Beaujard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Necker Enfants Malades Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dreux","sequence":"additional","affiliation":[{"name":"Department of Prenatal Biochemistry Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Czerkiewicz","sequence":"additional","affiliation":[{"name":"Department of Prenatal Biochemistry Robert Debr\u00e9 Hospital, AP\u2010HP  Paris 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2637"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610600618671"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)24044-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.294"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020796"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2347"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.080"},{"key":"e_1_2_5_9_1","first-page":"420","article-title":"First\u2010trimester fetal nuchal translucency thickness and risk for trisomies","volume":"84","author":"Pandya PP","year":"1994","journal-title":"Obstet 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