{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:23:44Z","timestamp":1769048624948,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Birth Defects Registry of the Massachusetts Department of Public Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To establish the frequency of prenatally undetected associated malformations (identified at birth) in infants with apparent \u201cisolated\u201d club foot deformity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort study of all infants with unilateral or bilateral club foot deformity identified at birth among 311\u2009480 infants surveyed between 1972 and 2012 at Brigham and Women's Hospital in Boston. Those with talipes equinovarus were divided into \u201cisolated\u201d and \u201ccomplex\u201d, based on the findings in examination and by chromosome analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and forty\u2010two infants had \u201cisolated\u201d talipes equinovarus (TEV), and 66 had the \u201ccomplex\u201d type. Six (4.2%) of the 142 infants with \u201cisolated\u201d TEV were found at birth to have associated malformations that had not been identified by imaging during pregnancy. These abnormalities included hip dislocation (<jats:italic>n<\/jats:italic>\u2009=\u20092), bilateral post\u2010axial polydactyly of the feet (<jats:italic>n<\/jats:italic>\u2009=\u20091), penile chordee (<jats:italic>n<\/jats:italic>\u2009=\u20091), and hypospadias (<jats:italic>n<\/jats:italic>\u2009=\u20092).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this consecutive series of infants with isolated talipes equinovarus, 95.8% had no additional malformations identified by examination at birth. None of the additional findings were severe enough to affect the medical prognosis of the affected infant. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4534","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T01:05:26Z","timestamp":1415927126000},"page":"254-257","source":"Crossref","is-referenced-by-count":15,"title":["Congenital talipes equinovarus: frequency of associated malformations not identified by prenatal ultrasound"],"prefix":"10.1002","volume":"35","author":[{"given":"M. Hassan","family":"Toufaily","sequence":"first","affiliation":[{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Department of Pediatrics Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Noel","family":"Westgate","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Department of Pediatrics Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis B.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Department of Pediatrics Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588407X187739"},{"key":"e_1_2_5_3_1","volume-title":"Common Malformations","author":"Holmes LB","year":"2012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4079"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7558"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00780.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2325-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000142718.53380.8f"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B7.16076"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70445-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2004.23.4.497"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181e78e4e"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.84B7.12689"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1596"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1984"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12020103.x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4534","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:09:18Z","timestamp":1696388958000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,29]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/pd.4534"],"URL":"https:\/\/doi.org\/10.1002\/pd.4534","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,29]]}}}