{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:21:33Z","timestamp":1777033293340,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to determine the fetal modified myocardial performance index (Mod\u2010MPI) and E\u2010wave\/A\u2010wave peak velocities (E\/A ratio) in deteriorating grades of intrauterine growth restriction (IUGR) and its link to adverse outcomes defined as perinatal death, hypoxic ischemic encephalopathy, neonatal resuscitation, neonatal cord pH &lt;7.15, intraventricular hemorrhage and bronchopulmonary dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Forty three pregnant women with IUGR defined as the abdominal circumference &lt;10th percentile for gestational age and umbilical resistance index &gt;2 standard deviations in the third trimester of pregnancy were matched for gestational age and maternal age with 43 women with appropriate\u2010for\u2010gestational\u2010age fetuses. The IUGR group was subdivided on the basis of multivessel Doppler anomalies into different grades of growth restriction. Mod\u2010MPI and E\/A ratio were determined and linked to perinatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median Mod\u2010MPI was significantly higher in growth\u2010restricted fetuses compared with controls (0.59 vs 0.37, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and increased with severity of IUGR, the classification of which was based on degree of abnormality of the umbilical resistance index, presence of arterial redistribution and degree of abnormality of the ductus venosus (DV) Doppler indices. A cut\u2010off Mod\u2010MPI value of 0.54 conferred a sensitivity of 87% [confidence interval (CI): 66\u201397%], specificity of 75% (CI: 55\u201391%) and a likelihood ratio (LR) of 3.47 for an adverse outcome. A cut\u2010off Mod\u2010MPI value of 0.67 conferred a sensitivity of 100% (CI: 54\u2013100%), specificity of 81% (CI: 65\u201392%) and LR of 5.28 for perinatal death. No abnormal outcomes occurred in controls. In logistic regression analysis, the MPI remained a significant predictor of adverse outcome after adjusting for gestational age of delivery, fetal weight, E\/A ratio, maternal age, DV Doppler indices, amniotic fluid index and umbilical artery resistance index [adjusted odds ratio, 95% CI: 2.60 (1.15\u20135.83), <jats:italic>p<\/jats:italic>\u2010value 0.02]. MPI fared significantly better than the E\/A ratio as a predictor of adverse outcome (area under the receiver operating characteristic curve of 0.94 and 0.76, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fetal myocardial performance deteriorates with severity of growth restriction. There is an association between severity of the MPI elevation and rates of adverse perinatal outcome. The Mod\u2010MPI and E\/A ratio have the potential to be integrated into routine surveillance techniques of the growth\u2010restricted fetus. \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4537","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T05:30:41Z","timestamp":1415943041000},"page":"266-273","source":"Crossref","is-referenced-by-count":35,"title":["Determination of the myocardial performance index in deteriorating grades of intrauterine growth restriction and its link to adverse outcomes"],"prefix":"10.1002","volume":"35","author":[{"given":"I.\u2009E.","family":"Bhorat","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2009S.","family":"Bagratee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pillay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nelson R Mandela School of Medicine University of KwaZulu Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Biostatistics Unit South African Medical Research Council  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"357","article-title":"New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function \u2013 a study in normal and dilated cardiomyopathy","volume":"26","author":"Tei 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