{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:52:34Z","timestamp":1782442354832,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study was to examine the prenatal anomalies in fetuses with Beckwith\u2013Wiedemann syndrome (BWS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included a retrospective assessment of 12 pregnancies that were seen at three tertiary referral centres (Universities of T\u00fcbingen, Bonn, and Cologne\/Germany). The genetic mutation, the results of the second trimester ultrasound examination, and the outcome of the pregnancies are shown. Biometric data were transformed into <jats:italic>z<\/jats:italic>\u2010values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median gestational age at the time of examination was 22.6 (range 19.0\u201329.7) weeks of gestation. In all cases, the head circumference (HC) and the femur length (FL) were within the normal range, but the HC\u2010FL ratio was above the 95th centile in 75% of the cases. An exomphalos, macroglossia, and visceromegaly were observed in 67%, 50%, and 83% of the cases, and in 58% and 83%, there were polyhydramnios and placentamegaly respectively. The fetal pancreas was identified in three quarters of the cases. A third of the women had large, overstimulation\u2010like ovaries, although each pregnancy was conceived naturally. In four cases, beta\u2010human chorionic gonadotropin (hCG) levels were measured and mean hCG levels were 498\u2009106\u2009IU\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Besides exomphalos, BWS should be considered if there is macroglossia, a distinct growth pattern, pancreatic hyperplasia, placentamegaly, and substantially increased levels of beta\u2010hCG. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4555","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T11:00:52Z","timestamp":1420542052000},"page":"394-399","source":"Crossref","is-referenced-by-count":42,"title":["Novel fetal and maternal sonographic findings in confirmed cases of Beckwith\u2013Wiedemann syndrome"],"prefix":"10.1002","volume":"35","author":[{"given":"Karl Oliver","family":"Kagan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Bonn  Bonn Germany"},{"name":"Department of Obstetrics and Gynaecology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Dufke","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Applied Genomics University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Geipel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hoopmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Abele","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"223","article-title":"Familial malformation complex with umbilical hernia and macroglossia\u2013a \u201cnew syndrome?\u201d","volume":"13","author":"Wiedemann HR","year":"1964","journal-title":"J Genet Hum"},{"key":"e_1_2_5_3_1","unstructured":"BeckwithJB.Extreme cytomegaly of the adrenal fetal cortex hyperplasia of the kidneys and pancreas and Leydig\u2010cell hyperplasia: another syndrome?Annual Meeting of Western Society for Pediatric Research Los Angeles CA 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