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OI is a genetic disorder primarily with defective type I collagen with a wide spectrum of clinical expression. In the more severe cases, it can be diagnosed before birth.<\/jats:p><jats:p>Transplantation of mesenchymal stem cells (MSC) has the potential to improve the bone structure and stability, growth and fracture healing. Prenatal and postnatal cell transplantation has been investigated in preclinical and clinical studies of OI and suggests that this procedure is safe and has positive effects. Cell transplantation resulted in improved linear growth, mobility and reduced fracture incidence. However, the effect is transient and for this reason re\u2010transplantation may be needed.<\/jats:p><jats:p>So far there is limited experience in this area, and proper studies are required to accurately determine if MSC transplantation is of clinical benefit in the treatment of OI. In this review, we summarize what is currently known in this field. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.4611","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T14:45:20Z","timestamp":1431355520000},"page":"827-832","source":"Crossref","is-referenced-by-count":23,"title":["Stem cell transplantation before birth \u2013 a realistic option for treatment of osteogenesis imperfecta?"],"prefix":"10.1002","volume":"35","author":[{"given":"Magnus","family":"Westgren","sequence":"first","affiliation":[{"name":"Center for Fetal Medicine Karolinska University Hospital  Stockholm Sweden"},{"name":"Division of Obstetrics and Gynaecology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"G\u00f6therstr\u00f6m","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Haematology and Regenerative Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.81"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36545"},{"key":"e_1_2_9_4_1","first-page":"813","article-title":"Morphologic studies in the skeletal dysplasias","volume":"96","author":"Sillence DO","year":"1979","journal-title":"Am J Pathol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2009.10.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3039"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01731"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907705"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.02.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.01.034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1505"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31334"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.141"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370196"},{"key":"e_1_2_9_15_1","first-page":"41","article-title":"Genetic screening of a pedigree with osteogenesis imperfecta type and identification of a novel mutation in COL1A2 pathogenic gene","volume":"37","author":"Rong L","year":"2015","journal-title":"Yi chuan"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2014.05.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000117"},{"volume-title":"Gene Reviews","year":"1993","author":"Steiner RD","key":"e_1_2_9_18_1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391402"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.08.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005088.pub3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2676"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6359"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31711"},{"key":"e_1_2_9_25_1","article-title":"Fetal skeletal dysplasias in a tertiary care center: radiology, pathology, and molecular analysis of 112 cases","author":"Barkova E","year":"2014","journal-title":"Clin Genet"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90662-7"},{"key":"e_1_2_9_27_1","first-page":"228","article-title":"Management of osteogenesis imperfecta in pregnancy. 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