{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:04:24Z","timestamp":1777784664027,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the outcome of fetuses who had sonographic features suggestive of Pierre Robin Sequence (PRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All prenatal ultrasounds that mentioned \u2018posterior cleft palate\u2019, or \u2018micro or retrognathia\u2019 or \u2018PRS\u2019 over 13 and 20\u2009years, respectively, at two obstetrical centers were reviewed. Medical records for children with isolated PRS monitored over 20\u2009years at a PRS referral center for prenatal anomalies and the severity of neonatal feeding and respiratory functional disorders were utilized for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a prenatal ultrasound database of 166\u2009000 cases, 157 had one or more of the sonographic signs suggestive of PRS and had follow\u2010up available. Of them, 33 (21%) had confirmed PRS, 9 (6%) were normal and 115 (73%) had chromosomal aberrations, associated malformations or neurological anomalies. Visualization of a posterior cleft palate in addition to retro\u2010micrognathia had a positive predictive value of 100% for PRS. The distribution of functional severity grades was similar in cases suspected prenatally as in 238 cases of PRS followed in the referral center in Necker Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only a minority of cases of fetal retrognathia have complete PRS; the majority have other severe conditions. Prenatal prediction of functional severity of isolated PRS is not possible. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4619","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T18:19:09Z","timestamp":1431713949000},"page":"853-858","source":"Crossref","is-referenced-by-count":25,"title":["Prenatal diagnosis of Pierre Robin Sequence: accuracy and ability to predict phenotype and functional severity"],"prefix":"10.1002","volume":"35","author":[{"given":"Katia","family":"Lind","sequence":"first","affiliation":[{"name":"General Pediatrics Department and Reference Center for Rare Diseases \u2018Syndromes de Pierre Robin et troubles de succion\u2010d\u00e9glutition cong\u00e9nitaux\u2019 Necker Hospital Paris France"},{"name":"Paris Descartes University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010C\u00e9cile","family":"Aubry","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Antoine B\u00e9cl\u00e8re Hospital Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Belarbi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Imaging Robert Debr\u00e9 Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Chalouhi","sequence":"additional","affiliation":[{"name":"General Pediatrics Department and Reference Center for Rare Diseases \u2018Syndromes de Pierre Robin et troubles de succion\u2010d\u00e9glutition cong\u00e9nitaux\u2019 Necker Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Couly","sequence":"additional","affiliation":[{"name":"Paris Descartes University Paris France"},{"name":"Maxillo\u2010facial Surgery Unit Necker Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Benachi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Antoine B\u00e9cl\u00e8re Hospital Clamart France"},{"name":"Universit\u00e9 Paris Sud Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislas","family":"Lyonnet","sequence":"additional","affiliation":[{"name":"Paris Descartes University Paris France"},{"name":"Genetics Department Necker Hospital Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Abadie","sequence":"additional","affiliation":[{"name":"General Pediatrics Department and Reference Center for Rare Diseases \u2018Syndromes de Pierre Robin et troubles de succion\u2010d\u00e9glutition cong\u00e9nitaux\u2019 Necker Hospital Paris France"},{"name":"Paris Descartes University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/08-061.1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195118612.001.0001","volume-title":"Syndromes of the Head and Neck. 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