{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:13:22Z","timestamp":1761920002563,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Arvo and Lea Ylpp\u00f6 foundation"},{"DOI":"10.13039\/501100008320","name":"Finnish Brain Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008320","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Helsinki University Research Grants"},{"name":"Paivikki and Sakari Sohlberg Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aim to study the gender impact on the pregnancy outcome and on the long\u2010term outcome of children after increased fetal nuchal translucency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All singleton pregnancies with increased nuchal translucency (\u22653\u2009mm until 1 March 2004 and \u226595th percentile thereafter) referred to Helsinki University Hospital from 2002 to 2007 with known gender and normal sex chromosomes were included. The pregnancy outcome (miscarriage, termination of pregnancy, perinatal death or delivery of a healthy\/unhealthy child) and the long\u2010term outcome (structural defects or neurodevelopmental impairment) were recorded from hospital databases and national registers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1011 fetuses, 600 were male and 411 were female, male\u2010to\u2010female ratio being 1.46\u2009:\u20091. This ratio decreased by increasing NT thickness, being 1\u2009:\u20091 when the NT was \u22654.0\u2009mm. The pregnancy outcome was better among male fetuses than among female fetuses (<jats:italic>p<\/jats:italic>\u2009=\u20090.049). There were more chromosomal abnormalities among the females than the males (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Among euploid fetuses, the pregnancy outcome and the long\u2010term outcome were equal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After increased nuchal translucency, the pregnancy outcome of male fetuses was better due to the lower incidence of chromosomal abnormalities compared with female fetuses. Among euploid fetuses, the pregnancy outcome and the long\u2010term outcome were equal. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4632","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T13:24:54Z","timestamp":1434720294000},"page":"901-905","source":"Crossref","is-referenced-by-count":3,"title":["The significance of gender in fetuses with increased nuchal translucency: pregnancy outcomes and long\u2010term outcomes of children"],"prefix":"10.1002","volume":"35","author":[{"given":"Outi","family":"\u00c4yr\u00e4s","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Helsinki University Hospital and University of Helsinki Finland  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Eronen","sequence":"additional","affiliation":[{"name":"Health Department The Social Insurance Institution of Finland  Helsinki 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