{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:14:07Z","timestamp":1789848847002,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell\u2010free DNA (cfDNA) testing is increasingly being used to screen pregnant women for fetal aneuploidies. This technology may also identify fetal sex and can be used to screen for sex chromosome aneuploidies (SCAs). Physicians offering this screening will need to be prepared to offer comprehensive prenatal counseling about these disorders to an increasing number of patients. The purpose of this article is to consider the source of information to use for counseling, factors in parental decision\u2010making, and the performance characteristics of cfDNA testing in screening for SCAs. Discordance between ultrasound examination and cfDNA results regarding fetal sex is also discussed. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.4639","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T05:39:13Z","timestamp":1434692353000},"page":"980-985","source":"Crossref","is-referenced-by-count":54,"title":["Cell\u2010free DNA screening and sex chromosome aneuploidies"],"prefix":"10.1002","volume":"35","author":[{"given":"Michael T.","family":"Mennuti","sequence":"first","affiliation":[{"name":"Department of OB\/GYN, Divisions of Maternal\u2010Fetal Medicine and Reproductive Genetics University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchitra","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN, Division of Maternal Fetal Medicine University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla","family":"Khalek","sequence":"additional","affiliation":[{"name":"Department of Pediatric General, Thoracic and Fetal Surgery, Center for Fetal Diagnosis and Treatment The Children's Hospital of Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Dugoff","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN, Divisions of Maternal\u2010Fetal Medicine and Reproductive Genetics University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.73"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182368a0e"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4126"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.029"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31824fb482"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.021"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.030"},{"key":"e_1_2_3_9_1","first-page":"59","article-title":"Sex chromosome aneuploidy: the Denver Prospective Study","volume":"26","author":"Robinson A","year":"1990","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340420"},{"key":"e_1_2_3_11_1","first-page":"225","article-title":"Summary of clinical findings in children and young adults with sex chromosome anomalies","volume":"26","author":"Robinson A","year":"1990","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320440319"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320530204"},{"key":"e_1_2_3_14_1","first-page":"3","article-title":"The incidence and etiology of sex chromosome abnormalities in man","volume":"15","author":"Jacobs PA","year":"1979","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0719"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10391"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2013.07.021"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10394"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005669"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.9.3198"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.1.164"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31350"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq027"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1354-7"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000128171.14081.eb"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der193"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4439"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2008.00828.x"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.374"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064198"},{"issue":"5","key":"e_1_2_3_31_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5858\/1999-123-0381-EAOMIA","article-title":"Extensive analysis of mosaicism in a case of Turner syndrome: the experience of 287 cytogenetic laboratories. 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