{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:10:36Z","timestamp":1782252636760,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"crossref","award":["PB-PG-0909-20228"],"award-info":[{"award-number":["PB-PG-0909-20228"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore factors that influence decision\u2010making in relation to prenatal diagnostic testing (PDT) for inherited retinal disease (IRD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Semi\u2010structured interviews were conducted with 50 adults with IRD, selected from a larger sample to provide a diversity of backgrounds and opinions on genetic testing. Interviews were transcribed verbatim and analysed using thematic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mostly participants supported PDT, believing that it would provide information to help them prepare for and plan the future care of the child and the potential for early access to emerging therapies. Opposition to PDT stemmed from its use to justify termination of pregnancy, with participants feeling that it was not justified as they retained a good quality of life despite their visual impairment. Participants raised concerns about the risk of PDT and the accuracy of the results. However, most suggested that it should be available as an option for others, but for specific reasons and not as a part of routine care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The variation in attitudes towards PDT and uncertainty about the risk and accuracy of results suggest that individuals at risk of having a child with IRD should have access to genetic counselling to support decision making. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4644","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T19:26:07Z","timestamp":1435692367000},"page":"913-918","source":"Crossref","is-referenced-by-count":11,"title":["Patient attitudes towards prenatal diagnostic testing for inherited retinal disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Khuram","family":"Ahmed","sequence":"first","affiliation":[{"name":"Eye Clinic, St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushtaq","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Yorkshire Regional Genetics Chapel Allerton Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Potrata","sequence":"additional","affiliation":[{"name":"Leeds Institute of Health Sciences University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Willis","sequence":"additional","affiliation":[{"name":"Leeds Institute of Health Sciences University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary L.","family":"Grant","sequence":"additional","affiliation":[{"name":"Leeds Institute of Health Sciences University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Allsop","sequence":"additional","affiliation":[{"name":"Leeds Institute of Health Sciences University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Hewison","sequence":"additional","affiliation":[{"name":"Leeds Institute of Health Sciences University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Downey","sequence":"additional","affiliation":[{"name":"Hull and East Yorkshire Eye Hospital  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gale","sequence":"additional","affiliation":[{"name":"York Teaching Hospital NHS Foundation Trust  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"McKibbin","sequence":"additional","affiliation":[{"name":"Eye Clinic, St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303434"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.2.252"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2009.02129.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810701199423"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2013.19"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.111"},{"key":"e_1_2_6_8_1","unstructured":"MooreT BurtonH.Genetic ophthalmology in focus: a needs assessment and review of specialist services for genetic eye disorders. 2008 April. 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