{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:28:00Z","timestamp":1762504080328},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to compare prenatal versus postnatal markers of congenital diaphragmatic hernia (CDH) severity at a single fetal\u2010care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed of patients having a complete prenatal evaluation and surgical repair (<jats:italic>n<\/jats:italic>\u2009=\u200955). Observed\u2010to\u2010expected lung\u2010to\u2010head ratio (o\/eLHR), observed\u2010to\u2010expected total lung volume (o\/eTLV), liver position (LP), a predictive dependent variable from logistic regression of o\/eLHR and liver position (o\/eLHR\u2009+\u2009LP), and diaphragmatic defect size per the CDH Study Group A\u2013D classification were plotted into receiver\u2013operating characteristics (ROC) curves. Survival and need for extracorporeal membrane oxygenation (ECMO) were primary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Survival was 69%, and ECMO utilization was 56%. Distribution was 80% left\u2010sided defects. In the survival ROC curve, the area under the curve (AUC) for o\/eLHR was 0.73, o\/eTLV 0.74, LP 0.73, o\/eLHR\u2009+\u2009LP 0.78, and defect size 0.84 (<jats:italic>p<\/jats:italic>\u2009=\u20090.23). The ROC curve for ECMO support showed o\/eLHR had an AUC of 0.82, o\/eTLV 0.89, LP 0.79, o\/eLHR\u2009+\u2009LP 0.87, and defect size 0.90 (<jats:italic>p<\/jats:italic>\u2009=\u20090.19). The AUCs were similar when only left\u2010sided CDH was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that prenatal evaluation was equivalent to the postnatal diaphragmatic defect classification for predicting survival and need for ECMO in CDH patients. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4721","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T03:14:45Z","timestamp":1446693285000},"page":"107-111","source":"Crossref","is-referenced-by-count":19,"title":["Prenatal and postnatal markers of severity in congenital diaphragmatic hernia have similar prognostic ability"],"prefix":"10.1002","volume":"36","author":[{"given":"N. L.","family":"Werner","sequence":"first","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery The University of Michigan Medical School and The C.S. Mott Children's Hospital and the Fetal Diagnosis and Treatment Center  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Coughlin","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery The University of Michigan Medical School and The C.S. Mott Children's Hospital and the Fetal Diagnosis and Treatment Center  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Kunisaki","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery The University of Michigan Medical School and The C.S. Mott Children's Hospital and the Fetal Diagnosis and Treatment Center  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hirschl","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery The University of Michigan Medical School and The C.S. Mott Children's Hospital and the Fetal Diagnosis and Treatment Center  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ladino\u2010Torres","sequence":"additional","affiliation":[{"name":"Section of Pediatric Radiology, Department of Radiology The University of Michigan Medical School and The C.S. Mott Children's Hospital and the Fetal Diagnosis and Treatment Center  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Berman","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology The University of Michigan Medical School and The C.S. Mott Children's Hospital and the Fetal Diagnosis and Treatment Center  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kreutzman","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery The University of Michigan Medical School and The C.S. Mott Children's Hospital and the Fetal Diagnosis and Treatment Center  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B.","family":"Mychaliska","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Department of Surgery The University of Michigan Medical School and The C.S. Mott Children's Hospital and the Fetal Diagnosis and Treatment Center  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306174"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.09.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522081955"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.09.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3890"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.02.048"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.09.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12445"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.20032"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3367"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.08.014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4052"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2618"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.1.r01ap18236"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90338-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13271"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.3"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4408"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.03.011"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3040"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2688"},{"issue":"1","key":"e_1_2_6_23_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.06.069","article-title":"Prenatal prognosis in isolated congenital diaphragmatic hernia","volume":"98","author":"Datin\u2010Dorriere V","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6234"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.10.021"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.12.036"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4721","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:19:18Z","timestamp":1696472358000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/pd.4721"],"URL":"https:\/\/doi.org\/10.1002\/pd.4721","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]}}}