{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:56:15Z","timestamp":1784130975593,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,27]],"date-time":"2015-12-27T00:00:00Z","timestamp":1451174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study is to assess the utility of an intermediate ultrasound scan at 16<jats:sup>+0<\/jats:sup> to 18<jats:sup>+6<\/jats:sup>\u2009weeks of gestation in euploid fetuses with increased nuchal translucency\u2009\u2265\u20093.5\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred eighty\u2010nine fetuses with nuchal translucency (NT)\u2009\u2265\u20093.5\u2009mm were identified in two prenatal centers between January 2008 and December 2012. Pregnancy work\u2010up included karyotyping, monthly detailed ultrasound scan starting with a 16th\u2010week scan, a cardioechography, and a genetic counseling. Abnormal findings and pregnancy outcomes were analyzed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 389 fetuses included, 52% had normal karyotype. Among euploid fetuses, 51 (30.7%) structural defects were identified overall. First\u2010trimester scan was useful to identify 16 of the major defects (31.3%), and the 16th\u2010week scan was useful to identify an additional 21 of them (41.2%), whereas the 22nd\u2010week pregnancy scan discovered an additional 14 (27.4%). Structural defects discovered with the 16th\u2010week scan were cardiac defects (<jats:italic>n<\/jats:italic>\u2009=\u20097), polymalformative syndromes (<jats:italic>n<\/jats:italic>\u2009=\u20093), left diaphragmatic hernias (<jats:italic>n<\/jats:italic>\u2009=\u20093), limbs abnormalities (<jats:italic>n<\/jats:italic>\u2009=\u20092), genitourinary (<jats:italic>n<\/jats:italic>\u2009=\u20092), microretrognathism (<jats:italic>n<\/jats:italic>\u2009=\u20092), hydrops (<jats:italic>n<\/jats:italic>\u2009=\u20091), and exomphalos (<jats:italic>n<\/jats:italic>\u2009=\u20091). If the intermediate scan was normal, the chances of a favorable outcome were as high as 85% and were close to 100% after 20\u2009weeks, irrespective of initial NT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The intermediate ultrasound was useful in fetuses with increased NT pregnancy work\u2010up. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4756","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T15:58:42Z","timestamp":1449849522000},"page":"148-153","source":"Crossref","is-referenced-by-count":18,"title":["The performance of an intermediate 16th\u2010week ultrasound scan for the follow\u2010up of euploid fetuses with increased nuchal translucency"],"prefix":"10.1002","volume":"36","author":[{"given":"Maela","family":"Le Lous","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Poissy\u2010Saint Germain Hospital, Versailles\u2010Saint Quentin University  Versailles France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bouhanna","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Poissy\u2010Saint Germain Hospital, Versailles\u2010Saint Quentin University  Versailles France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Colmant","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AP\u2010HP Kremlin\u2010Bic\u00eatre Hospital, University of Paris\u2010Sud  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rozenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Poissy\u2010Saint Germain Hospital, Versailles\u2010Saint Quentin University  Versailles 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