{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T21:28:30Z","timestamp":1774906110275,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to assess the perinatal outcome in monochorionic diamniotic (MD) twin pregnancies complicated by amniotic fluid discordance (AFD) adjoining twin\u2013twin transfusion syndrome (TTTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational study of 84 consecutive MD twin pregnancies complicated by AFD that resembled TTTS was conducted. AFD adjoining TTTS was defined by a maximal vertical pocket of amniotic fluid \u22643\u2009cm in one twin and \u22657\u2009cm in the other excluding TTTS. The study population was divided into two groups, group 1 and group 2, according to positive and absent or reversed end\u2010diastolic flow (AREDF) in the umbilical artery, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen of the 35 (42.9%) group 1 cases and 30 of the 49 (61.2%) group 2 cases progressed to TTTS. The overall survival and intact survival rate in constant AFD that never progressed to TTTS in group 1 was 100% (40\/40) and 90% (36\/40), respectively. The overall survival and intact survival rate of constant AFD in group 2 with selective intrauterine growth restriction (sIUGR) was 54.2% (13\/24) and 41.7% (10\/24), respectively, and for those without sIUGR was 64.3% (9\/14) and 57.1% (8\/14), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Constant AFD with AREDF in the umbilical artery represents an extremely high risk for adverse outcomes regardless of the presence of sIUGR. \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4765","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T21:52:39Z","timestamp":1451425959000},"page":"170-176","source":"Crossref","is-referenced-by-count":10,"title":["Outcome of monochorionic twin pregnancies with moderate amniotic fluid discordance adjoining twin\u2013twin transfusion syndrome"],"prefix":"10.1002","volume":"36","author":[{"given":"Satoshi","family":"Hayashi","sequence":"first","affiliation":[{"name":"Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Anami","sequence":"additional","affiliation":[{"name":"Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology National Hospital Organization Beppu Medical Center  Beppu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari S.","family":"Oba","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Graduate school of Medicine Yokohama City University  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Fetal\u2013Maternal Medicine Nagara Medical Center  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Toho University Omori Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Murotsuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Miyagi Children's Hospital  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Murakoshi","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Maternal 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