{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:47:11Z","timestamp":1772502431422,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to determine whether prenatal ultrasound findings and cord blood N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT pro\u2010BNP) and cardiac troponin T (cTnT) can predict neonatal mortality in single ventricle congenital heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The association between neonatal mortality and prenatal ultrasound findings\/cord blood biomarkers was evaluated in neonates delivered with a diagnosis of single ventricle congenital heart disease. The presence of prenatal ultrasound findings suggesting systemic outflow obstruction (ascending aorta &lt;2.5 percentile) or ventricular dysfunction (the presence of cardiomegaly or hydrops) was evaluated, and the total number of abnormal findings was converted to a numeric score called the \u2018single ventricle score\u2019. In addition, NT pro\u2010BNP and cTnT were measured in cord blood taken at the time of delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 48 cases of single ventricle congenital heart disease were included. The rate of neonatal mortality was 31% (15\/48). The presence of either abnormal ultrasound findings(single ventricle score\u2009\u2265\u20092) or elevated concentrations of NT pro\u2010BNP or cTnT was associated with increased risk of neonatal death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of either abnormal prenatal ultrasound findings or increased cord blood NT pro\u2010BNP and cTnT concentrations was associated with the risk of neonatal death in single ventricle congenital heart disease. \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4787","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T05:34:00Z","timestamp":1454564040000},"page":"346-352","source":"Crossref","is-referenced-by-count":11,"title":["Prenatal prediction of neonatal death in single ventricle congenital heart disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Seung Mi","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Korea"},{"name":"Department of Obstetrics and Gynecology Seoul Metropolitan Government Seoul National University Boramae Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Eun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi. 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