{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:16:23Z","timestamp":1777158983850,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:00:00Z","timestamp":1461456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate rates of progression, regression and stabilisation and outcomes for stage I twin\u2013twin transfusion syndrome (TTTS) and significant liquor discordant (LD) monochorionic diamniotic (MCDA) twins referred to the New South Wales Fetal Therapy Centre between June 2007 and May 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of 329 monochorionic referrals, of whom 47 had LD and 28 had stage I TTTS at presentation; 43 were stage I or higher at any time during surveillance. Clinical progression, rates of therapy, survival and associated complications were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of stage I cases, 64% (18\/28) remained stable or regressed, with 60% (6\/10) of those progressing becoming at least stage II within 2\u2009weeks. Of LD cases, 7\/47 (15%) progressed to stage I TTTS, 8\/47 (17%) to stage II or higher and 3\/47 (6%) to selective intrauterine growth restriction (38% total).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While a stable clinical picture was the most common outcome in stage I\/LD presentations, progression to stage\u2009\u2265\u2009II TTTS occurred in 36 and 17% respectively, indicating that LD is not a benign finding. Rapid progression in the majority of progressive cases and modest overall survival rates support close surveillance of these pregnancies and investigation of laser therapy as a first\u2010line treatment of stage I TTTS. \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4814","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:04:53Z","timestamp":1458371093000},"page":"507-514","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of stage I TTTS or liquor discordant twins: a single\u2010centre review"],"prefix":"10.1002","volume":"36","author":[{"given":"Ellen","family":"Hinch","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Henry","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Maternal Fetal Medicine Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Wilson","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alec W.","family":"Welsh","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Maternal Fetal Medicine Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200304000-00013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5189"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.050"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313300"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2655"},{"key":"e_1_2_6_7_1","first-page":"399","article-title":"'Pseudo' twin\u2010to\u2010twin transfusion syndrome and fetal outcome","volume":"18","author":"Mari G","year":"1998","journal-title":"Perinatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7612"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200104000-00015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(03)00051-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2007.00712.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.02.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.07.007"},{"issue":"6","key":"e_1_2_6_15_1","first-page":"1257","article-title":"Validation of the Quintero staging system for twin\u2010twin transfusion syndrome","volume":"100","author":"Taylor MJO","year":"2002","journal-title":"Obst Gynecol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.05.034"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.01127.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7566"},{"issue":"1","key":"e_1_2_6_19_1","first-page":"5","article-title":"Survival outcomes of twin\u2010twin transfusion syndrome stage I: a systematic review of literature","volume":"30","author":"Rossi AC","year":"2013","journal-title":"Am J Perinatol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.16.2.95.101"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032597"},{"key":"e_1_2_6_22_1","unstructured":"VilleY.Randomized controlled trial comparing a conservative management and laser surgery (TTTS1) clinicaltrials.gov2013[cited201316\/10\/2013]."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70291-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0654-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8802"},{"key":"e_1_2_6_26_1","unstructured":"RANZCOG RAaNZCoOaG.Management of monochorionic twin pregnancy (Guideline C\u2010obs 42)2014[June 30 2015]. 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