{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:06:58Z","timestamp":1772492818852,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To perform a morphological evaluation of the ductus venosus, heart and jugular lymphatic sac (JLS) in first\u2010trimester human fetuses with normal and abnormal ductus venosus flow velocity waveforms (DV\u2010FVWs) and normal and increased nuchal translucency (NT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Postmortem examination was performed on fetuses with increased NT or structural malformations with previous NT and DV\u2010FVW measurements. Ductus venosus morphology was examined using markers for endothelium, smooth muscle actin (SMA), nerves and elastic fibers. Fetal hearts were studied by microscopy. The nuchal region was analyzed using markers for lymphatic vessels, endothelium, SMA and nerves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two trisomy 21 and two trisomy 18 fetuses with increased NT and abnormal DV\u2010FVWs were analyzed. As a control, one euploid anencephalic fetus with normal NT, cardiac anatomy and DV\u2010FVWs was examined. Similar endothelial and SMA expression was observed in the ductus venosus in all fetuses. Nerve and elastic fiber expression were not detected. Three trisomic fetuses showed cardiac defects, one trisomic fetus demonstrated normal cardiac anatomy. The JLS was abnormally enlarged or contained red blood cells in all trisomic fetuses. The control fetus showed a normal JLS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal DV\u2010FVWs are not justified by alterations in ductus venosus morphology. DV\u2010FVWs most probably reflect intracardiac pressure. \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4820","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T13:23:20Z","timestamp":1460294600000},"page":"537-544","source":"Crossref","is-referenced-by-count":2,"title":["Absence of an anatomical origin for altered ductus venosus flow velocity waveforms in first\u2010trimester human fetuses with increased nuchal translucency"],"prefix":"10.1002","volume":"36","author":[{"given":"Nicole B.","family":"Burger","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Matias","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Sao Jo\u00e3o  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelien","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Embryology &amp; Physiology Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christianne J. 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