{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:58:59Z","timestamp":1792180739813,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Functionally univentricular hearts (UVHs) represent cardiac anomalies in which either the pulmonary or systemic circulation cannot be supported independently. The purpose of our study was to determine perinatal outcomes after prenatal diagnosis of functionally UVH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated patients who presented between 2008 and June 2015 in our centre and in prenatal practice praenatal.de in Cologne. We included double inlet left ventricle (DILV), tricuspid valve atresia (TA), pulmonary valve atresia and intact ventricular septum (PA:IVS), unbalanced atrioventricular septal defect (AVSD), heterotaxy, hypoplastic left heart syndrome (HLHS) and hypoplastic left heart complex (HLHC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of initially 155 patients, 128 were liveborn (82.6%). Ten neonates (7.8%) were lost to follow\u2010up, in three (2.5%) neonates, parents decided for compassionate care. Overall survival after prenatal diagnosis of functionally UVH was 67.1%, and 90.4% on an intention\u2010to\u2010treat basis. Survival after surgery reached 93.7%. The majority of deaths occurred within the group of dominant RV (10\/74, 13.5%). High risk HLHS with restrictive foramen ovale was associated with the lowest survival rate (13\/17, 76.5%) with significant difference compared to survival rate in dominant LV (40\/41, 97.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results should be explained to parents to ensure informed decisions and counselling. \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4821","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:30:28Z","timestamp":1460313028000},"page":"545-554","source":"Crossref","is-referenced-by-count":15,"title":["Prenatal diagnosis of functionally univentricular heart, associations and perinatal outcomes"],"prefix":"10.1002","volume":"36","author":[{"given":"Aline","family":"Wolter","sequence":"first","affiliation":[{"name":"University Hospital UKGM, Justus\u2010Liebig University Department of OB\/GYN, Division of Prenatal Medicine  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Nosb\u00fcsch","sequence":"additional","affiliation":[{"name":"University Hospital UKGM, Justus\u2010Liebig University Department of OB\/GYN, Division of Prenatal Medicine  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Kawecki","sequence":"additional","affiliation":[{"name":"University Hospital UKGM, Justus\u2010Liebig University Department of OB\/GYN, Division of Prenatal Medicine  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Degenhardt","sequence":"additional","affiliation":[{"name":"University Hospital UKGM, Justus\u2010Liebig University Department of OB\/GYN, Division of Prenatal Medicine  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Enzensberger","sequence":"additional","affiliation":[{"name":"University Hospital UKGM, Phillips University Department of OB\/GYN, Division of Prenatal Medicine  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Graupner","sequence":"additional","affiliation":[{"name":"University Hospital, Klinikum rechts der Isar Technische Universit\u00e4t, Department of OB\/GYN  M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Vorisek","sequence":"additional","affiliation":[{"name":"University Hospital UKGM, Justus\u2010Liebig University Department of OB\/GYN, Division of Prenatal Medicine  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Akint\u00fcrk","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, University Hospital, Justus\u2010Liebig University Division of Pediatric Heart Surgery  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Yerebakan","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, University Hospital, Justus\u2010Liebig University Division of Pediatric Heart Surgery  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Khalil","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, University Hospital, Justus\u2010Liebig University Division of Pediatric Cardiology  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Schranz","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center, University Hospital, Justus\u2010Liebig University Division of Pediatric Cardiology  Giessen 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