{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:41:49Z","timestamp":1781037709640,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study is to report the performance of noninvasive prenatal testing (NIPT) in twin pregnancies after the treatment of assisted reproductive technology (ART).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In two years period, 565 pregnant women with ART twin pregnancies were prospectively tested by NIPT for screening for trisomy 21 (T21), 18 (T18), and 13 (T13) by sequencing cell\u2010free DNA in maternal plasma. Positive NIPT results were confirmed by karyotyping, while negative results were interviewed after delivery. Pregnant decision based on NIPT and confirmation results was discussed during post\u2010test counseling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total of 565 cases, NIPT had a failure rate of 0.9% (5\/565). Four cases of T21 were identified by NIPT and confirmed by karyotyping, resulting in 100% (95%CI 39.8%\u2013100%) positive predictive value. Among 556 cases with NIPT negative results, 506 cases (91.0%) were confirmed by follow\u2010up of postnatal phenotypes, while 33 cases (5.9%) had adverse pregnant outcomes with unconfirmed reasons because of the lack of cytogenetic samples. The remaining 17 cases (3.1%) refused follow\u2010up. No false negative result was reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With apparently high positive predictive value and low false positive rate, NIPT has the potential to be used as a good alternative approach of conventional prenatal screening at the first trimester in ART twin pregnancy. \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4837","type":"journal-article","created":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T11:52:51Z","timestamp":1462535571000},"page":"672-679","source":"Crossref","is-referenced-by-count":53,"title":["Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center"],"prefix":"10.1002","volume":"36","author":[{"given":"Yueqiu","family":"Tan","sequence":"first","affiliation":[{"name":"Institute of Reproductive and Stem Cell Engineering Central South University  Changsha China"},{"name":"Key Laboratory of Reproductive and Stem Cell Engineering Ministry of Health  Changsha China"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[{"name":"BGI\u2010Shenzhen  Shenzhen China"},{"name":"China National Genebank\u2010Shenzhen BGI\u2010Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Stem Cell Engineering Central South University  Changsha China"},{"name":"Key Laboratory of Reproductive and Stem Cell Engineering Ministry of Health  Changsha China"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Fu","sequence":"additional","affiliation":[{"name":"Clinical laboratory of BGI Health BGI\u2010Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Yin","sequence":"additional","affiliation":[{"name":"BGI\u2010Shenzhen  Shenzhen China"},{"name":"China National Genebank\u2010Shenzhen BGI\u2010Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Stem Cell Engineering Central South University  Changsha China"},{"name":"Key Laboratory of Reproductive and Stem Cell Engineering Ministry of Health  Changsha China"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of BGI Health BGI\u2010Wuhan  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Stem Cell Engineering Central South University  Changsha China"},{"name":"Key Laboratory of Reproductive and Stem Cell Engineering Ministry of Health  Changsha China"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of BGI Health BGI\u2010Wuhan  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Clinical laboratory of BGI Health BGI\u2010Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"BGI\u2010Shenzhen  Shenzhen China"},{"name":"China National Genebank\u2010Shenzhen BGI\u2010Shenzhen  Shenzhen China"},{"name":"Section of Molecular Disease Biology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuman","family":"Jiang","sequence":"additional","affiliation":[{"name":"Clinical laboratory of BGI Health BGI\u2010Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical laboratory of BGI Health BGI\u2010Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiu","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Reproductive and Stem Cell Engineering Ministry of Health  Changsha China"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gong","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Stem Cell Engineering Central South University  Changsha China"},{"name":"Key Laboratory of Reproductive and Stem Cell Engineering Ministry of Health  Changsha China"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"BGI\u2010Shenzhen  Shenzhen China"},{"name":"Clinical laboratory of BGI Health BGI\u2010Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem053"},{"issue":"7","key":"e_1_2_7_3_1","first-page":"1","article-title":"Assisted reproductive technology surveillance\u2010\u2010United States, 2009","volume":"61","author":"Sunderam S","year":"2012","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.10.017"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.077"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep035"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi027"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den103"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6254"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2000.440505.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13278"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1111::AID-PD998>3.0.CO;2-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2495"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.809"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08186.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000193005.42910.35"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2184"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.390"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200003)20:3<221::AID-PD787>3.0.CO;2-S"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.029"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31824fb482"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-5-57"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182368a0e"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.73"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4303"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.733768"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det271"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13277"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4002"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14792"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115584445"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3892"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14690"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000001"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.627"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200002)20:2<91::AID-PD759>3.0.CO;2-X"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.03.080"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000271995"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den291"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm3030679"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4123"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.042"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311037"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407349"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del367"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.05.030"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg308"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq023"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.4837","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.4837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:34:09Z","timestamp":1696466049000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.4837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/pd.4837"],"URL":"https:\/\/doi.org\/10.1002\/pd.4837","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,7]]}}}