{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:05:56Z","timestamp":1790049956515,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The cavum septi pellucidi (CSP) is an easily recognizable landmark in the fetal brain. CSP disappears after birth to form the septum pellucidum. Children with microdeletion 22q11 (del. 22q11) were, however, reported to have a persistent dilated CSP. This study was designed to examine whether the CSP is dilated in fetuses with del.22q11.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2013control study where the CSP width was measured in normal fetuses from 16 to 34\u2009weeks and in fetuses with del. 22q11. CSP width was correlated to the biparietal diameter (BPD). Reference curves were constructed, and z\u2010scores calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cavum septi pellucidi width in 260 normal fetuses showed a linear correlation with BPD. The study group consisted of 37 fetuses with del. 22q11. In 25\/37 (67.5%) of fetuses with del. 22q11, the CSP was enlarged with a mean z\u2010score of 2.64 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Fetuses with a BPD\u2009&gt;\u200950 mm (&gt;22 weeks of gestation) had a dilated CSP in 85.7% (24\/28).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CSP is a structure routinely evaluated in screening ultrasound. A wide CSP is found in second trimester fetuses with del. 22q11. A dilated CSP may be an important sonographic marker for the presence of del. 22q11 along with conotruncal malformations and thymic hypoplasia. \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.4911","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T00:24:39Z","timestamp":1470702279000},"page":"911-915","source":"Crossref","is-referenced-by-count":39,"title":["Dilated cavum septi pellucidi in fetuses with microdeletion 22q11"],"prefix":"10.1002","volume":"36","author":[{"given":"Rabih","family":"Chaoui","sequence":"first","affiliation":[{"name":"Center for Prenatal Diagnosis and Human Genetics  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Sven","family":"Heling","sequence":"additional","affiliation":[{"name":"Center for Prenatal Diagnosis and Human Genetics  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine of the Department of Obstetrics &amp; Gynecology Eastern Virginia Medical School  Norfolk VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sinkovskaya","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine of the Department of Obstetrics &amp; Gynecology Eastern Virginia Medical School  Norfolk VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Abuhamad","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine of the Department of Obstetrics &amp; Gynecology Eastern Virginia Medical School  Norfolk VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Karl","sequence":"additional","affiliation":[{"name":"Center for Prenatal Diagnosis  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3909"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273463"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1787"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2751"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12505"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2208"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12393"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.10.009"},{"key":"e_1_2_6_10_1","unstructured":"JonesKL JonesMC delCampoM.Smith's recognizable patterns of human malformation. 7 ed. 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