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The introduction of genome\u2010wide chromosomal microarray analysis to prenatal clinical diagnostic testing has increased the detection of pathogenic 22q11.2 deletions, which cause the most common genomic disorder. The recent addition of this and other microdeletions to non\u2010invasive prenatal screening methods using cell\u2010free fetal DNA has further propelled interest in outcomes. Conditions associated with 22q11.2 deletions include intellect ranging from intellectual disability to average, schizophrenia and other treatable psychiatric conditions, epilepsy, and early\u2010onset Parkinson's disease. However, there is currently no way to predict how severe the lifetime expression will be. Available evidence suggests no major role in these neuropsychiatric outcomes for the congenital cardiac or most other structural anomalies that may be detectable on ultrasound. This article provides an outline of the lifetime neuropsychiatric phenotype of 22q11.2 deletion syndrome that will be useful to clinicians involved in prenatal diagnosis and related genetic counselling. The focus is on information that will be most relevant to two common situations: detection of a 22q11.2 deletion in a fetus or newborn, and new diagnosis of 22q11.2 deletion syndrome in a parent without a previous molecular diagnosis. \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.4935","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T06:39:41Z","timestamp":1476340781000},"page":"61-69","source":"Crossref","is-referenced-by-count":14,"title":["Neuropsychiatric aspects of 22q11.2 deletion syndrome: considerations in the prenatal setting"],"prefix":"10.1002","volume":"37","author":[{"given":"Anne S.","family":"Bassett","sequence":"first","affiliation":[{"name":"The Dalglish Family 22q Clinic University Health Network Toronto Ontario Canada"},{"name":"Department of Mental Health Toronto General Research Institute, University Health Network Toronto Ontario Canada"},{"name":"Clinical Genetics Research Program Centre for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Costain","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Toronto Ontario Canada"},{"name":"Medical Genetics Residency Training Program University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian R.","family":"Marshall","sequence":"additional","affiliation":[{"name":"The Centre for Applied Genomics and Program in Genetics and Genome Biology The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Ontario 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