{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:32:18Z","timestamp":1762374738286},"reference-count":27,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2002,12,4]],"date-time":"2002-12-04T00:00:00Z","timestamp":1038960000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess whether the uptake of prenatal screening for trisomy 21 in a subsequent pregnancy is influenced by being classified in the \u2018increased risk\u2019 or \u2018not at increased risk\u2019 group in the first pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>District General Hospital Maternity Unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Amongst a group of women attending for maternity care at this hospital, the maternity records were examined to find women having at least two pregnancies. Any prenatal screening record for each pregnancy was retrieved from the prenatal screening database.<\/jats:p><jats:p>Prenatal screening for trisomy 21 was by a combination of maternal serum \u03b1\u2010fetoprotein (AFP) and free \u03b2\u2010human chorionic gonadotrophin (\u03b2\u2010hCG) in the second trimester and by maternal serum free \u03b2\u2010hCG and pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and fetal nuchal translucency (NT) thickness in the first trimester.<\/jats:p><jats:p>Women were stratified according to their trisomy 21 risk into an \u2018increased risk\u2019 group (1: &lt;250 in the second trimester and 1: &lt;300 in the first trimester) or \u2018not at increased risk\u2019 group based on their first pregnancy. In a second pregnancy, the records were examined to see if the mother accepted prenatal screening in the second pregnancy. The rate of acceptance of screening in a subsequent pregnancy, depending on whether \u2018at increased risk\u2019 or \u2018not at increased risk\u2019 in the first pregnancy, was examined using chi square tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the second trimester study, 4601 women were identified with two pregnancies during the study period. Of these, 4559 women had prenatal screening in a subsequent pregnancy. Initially, 273 women were identified in the high\u2010risk group, and of these 252 (92.3%) elected to have prenatal screening in a subsequent pregnancy. This compared with 4307 of 4328 (99.5%) women in the low\u2010risk group.<\/jats:p><jats:p>In the first trimester study, 1077 women were identified with two pregnancies during the study period. Of these, 1072 had prenatal screening in a subsequent pregnancy. Initially, 60 women were identified in the high\u2010risk group, and of these 56 (93.3%) elected to have prenatal screening in a subsequent pregnancy. This compared with 1016 of 1017 (99.9%) in the low\u2010risk group.<\/jats:p><jats:p>Statistically, there was no difference between the rate of declining prenatal screening in a second pregnancy amongst those in the high\u2010risk group in a first pregnancy or those in the low\u2010risk group (<jats:italic>p<\/jats:italic> = 0.429 for second trimester screening and <jats:italic>p<\/jats:italic> = 0.794 for first trimester screening). Similarly, no difference could be demonstrated between rates when screening in the first or second trimester (<jats:italic>p<\/jats:italic> = 0.961) for those in the high\u2010risk group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the understandable anxiety associated with being identified in the high\u2010risk group (as a false positive finding) in a previous pregnancy, this did not seem to deter women from accepting prenatal screening in a subsequent pregnancy. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.504","type":"journal-article","created":{"date-parts":[[2002,12,12]],"date-time":"2002-12-12T13:58:36Z","timestamp":1039701516000},"page":"1229-1232","source":"Crossref","is-referenced-by-count":11,"title":["Uptake of prenatal screening for chromosomal anomalies: impact of test results in a previous pregnancy"],"prefix":"10.1002","volume":"22","author":[{"given":"Kevin","family":"Spencer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110607"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/23.4.292"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90428-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.245"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199104000-00007"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90583-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140416"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.314"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1611(200009\/10)9:5<402::AID-PON475>3.0.CO;2-U"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(89)90101-3"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(92)90076-E"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970120309"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/01674829309084441"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970151304"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10006"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jms.8.3.145"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.208.1.9646820"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jms.7.1.4"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(84)90010-2"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/clinchem\/37.6.809","article-title":"Evaluation of an assay of the free \u03b2\u2010subunit of choriogonadotropin and its potential value in screening for Down's syndrome","volume":"37","author":"Spencer K","year":"1991","journal-title":"Clin Chem"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199701)17:1<39::AID-PD35>3.0.CO;2-N"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08183.x"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11619.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.94"},{"key":"e_1_2_1_26_1","first-page":"403","article-title":"Point of care screening for chromosomal anomalies in the first trimester of pregnancy","volume":"48","author":"Spencer K","year":"2002","journal-title":"Clin Chem"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.430"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11090-X"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T04:41:33Z","timestamp":1696740093000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":27,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1002\/pd.504"],"URL":"https:\/\/doi.org\/10.1002\/pd.504","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}