{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:22:40Z","timestamp":1762917760022,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Agence de la Biomedecine,","award":["Project SPINALPHA N\u00b013-18\/89"],"award-info":[{"award-number":["Project SPINALPHA N\u00b013-18\/89"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Shifting screening for trisomy 21 to the first trimester has resulted in the loss of maternal serum alpha\u2010fetoprotein screening for spina bifida. The aim of this study was to study the impact on open spina bifida prenatal screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>We reviewed prenatally diagnosed cases of spina bifida over three years: 2009 (only second\u2010trimester screening, MSM2T), 2010 (transient period) and 2011 (majority first\u2010trimester screening, MSM1T). Cases were assigned to three groups based on maternal serum markers (MSM2T, MSM1T and \u2018not performed\u2019). Gestational age at diagnosis of spina bifida was compared between these three groups and between the years 2009 and 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median gestational ages at diagnosis of the 742 spina bifida cases between the three groups were 22\u00a0weeks [18<jats:sup>+6<\/jats:sup>\u201323], 22<jats:sup>+1<\/jats:sup>\u00a0weeks [21<jats:sup>+3<\/jats:sup>\u201323] and 21<jats:sup>+4<\/jats:sup>\u00a0weeks [14<jats:sup>+1<\/jats:sup>\u201323], respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005). The diagnosis was made at 14\u201320\u00a0weeks in 34.7% for MSM2T group versus 8.5% for MSM1T (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Spina bifida diagnosis at 14\u201320\u00a0weeks declined from 38.8% in 2009 to 13.3% in 2011 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Loss of maternal serum alpha\u2010fetoprotein had a tangible effect on the gestational age at diagnosis of spina bifida and resulted in a decrease of 25% of cases of spina bifida detected before 20\u00a0weeks. \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5064","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T20:57:42Z","timestamp":1493413062000},"page":"673-679","source":"Crossref","is-referenced-by-count":5,"title":["Impact on spina bifida screening of shifting prenatal Down syndrome maternal serum screening from the second trimester to the first"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-565X","authenticated-orcid":false,"given":"Emmanuel","family":"Spaggiari","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Necker\u2010Enfants Malades Hospital, AP\u2010HP  Paris France"},{"name":"University Paris Descartes and Sorbonne Paris\u2010Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dreux","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\u2010Hormonology Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien J.","family":"Stirnemann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Necker\u2010Enfants Malades Hospital, AP\u2010HP  Paris France"},{"name":"University Paris Descartes and Sorbonne Paris\u2010Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Czerkiewicz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\u2010Hormonology Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Houfflin\u2010Debarge","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHU  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Segonne","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\u2010Hormonology Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marie","family":"Jouannic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Armand Trousseau Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Ville","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Necker\u2010Enfants Malades Hospital, AP\u2010HP  Paris France"},{"name":"University Paris Descartes and Sorbonne Paris\u2010Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francoise","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\u2010Hormonology Robert Debr\u00e9 Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5949"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)92839-6"},{"key":"e_1_2_5_5_1","first-page":"214","article-title":"Second\u2010trimester maternal serum alpha\u2010fetoprotein elevation and its association with adverse maternal\/fetal outcome: ten years experience","volume":"78","author":"Anfuso S","year":"2007","journal-title":"Acta Biomed"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00151-8"},{"key":"e_1_2_5_7_1","first-page":"1323","article-title":"Maternal serum\u2010alpha\u2010fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy. 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