{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:55:31Z","timestamp":1786478131296,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p><jats:bold>What's already known about this topic?<\/jats:bold><jats:list list-type=\"bullet\"><jats:list-item><jats:p>Low levels of PAPP\u2010A are associated with small for gestational age and PE.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:bold>What does this study adds?<\/jats:bold><jats:list list-type=\"bullet\"><jats:list-item><jats:p>NT, CRL and PAPP\u2010A are independent prognostic markers for adverse pregnancy outcome. Further work is required to assess the predictive ability of these factors in prediction models.<\/jats:p><\/jats:list-item><\/jats:list>\u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.5069","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T23:16:44Z","timestamp":1495063004000},"page":"705-711","source":"Crossref","is-referenced-by-count":19,"title":["Association of maternal serum PAPP\u2010A levels, nuchal translucency and crown\u2013rump length in first trimester with adverse pregnancy outcomes: retrospective cohort study"],"prefix":"10.1002","volume":"37","author":[{"given":"Ashwini","family":"Bilagi","sequence":"first","affiliation":[{"name":"Institute of Metabolism and Systems Research University of Birmingham Birmingham UK"},{"name":"Centre for Women and New\u2010born Health Birmingham Health Partners Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-1151","authenticated-orcid":false,"given":"Danielle L.","family":"Burke","sequence":"additional","affiliation":[{"name":"Research Institute for Primary Care and Health Sciences Keele University Staffordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Riley","sequence":"additional","affiliation":[{"name":"Research Institute for Primary Care and Health Sciences Keele University Staffordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Mills","sequence":"additional","affiliation":[{"name":"Centre for Women and New\u2010born Health Birmingham Health Partners Birmingham UK"},{"name":"Clinical Biochemistry Birmingham Women's Hospital NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Kilby","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research University of Birmingham Birmingham UK"},{"name":"Centre for Women and New\u2010born Health Birmingham Health Partners Birmingham UK"},{"name":"Fetal Medicine Centre Birmingham Women's Hospital NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Katie Morris","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research University of Birmingham Birmingham UK"},{"name":"Centre for Women and New\u2010born Health Birmingham Health Partners Birmingham UK"},{"name":"Fetal Medicine Centre Birmingham Women's Hospital NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.3149"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.052"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.068"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000191302.79560.d8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1898"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2116"},{"key":"e_1_2_7_8_1","unstructured":"RCOG.The investigation and management of the small\u2010for\u2010gestational\u2010age fetus. Greentop Guideline NO 31: RCOG; 2014."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-8-33"},{"issue":"2","key":"e_1_2_7_10_1","first-page":"145","article-title":"The efficacy of first\u2010trimester PAPP\u2010A and free beta hCG levels for predicting adverse pregnancy outcome","volume":"34","author":"Kavak ZN","year":"2006","journal-title":"J Perinat Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5206"},{"key":"e_1_2_7_12_1","article-title":"Prognosis research strategy (PROGRESS) 1: a framework for researching clinical outcomes","author":"Hemingway H","year":"2013","journal-title":"BMJ (Clinical research ed)"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001380"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001381"},{"key":"e_1_2_7_15_1","article-title":"Prognosis research strategy (PROGRESS) 4: stratified medicine research","author":"Hingorani AD","year":"2013","journal-title":"BMJ (Clinical research ed)"},{"key":"e_1_2_7_16_1","unstructured":"2016 [cited 2016 18\/2\/2016];https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/456654\/FASP_programme_handbook_August_2015.pdf]. Available from:"},{"key":"e_1_2_7_17_1","unstructured":"https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/6871\/1871208.pdf. 2016 [cited 2016 18\/2\/2016]."},{"key":"e_1_2_7_18_1","article-title":"The 11\u201313+6\u00a0weeks scan","author":"Nicolaides KH","year":"2004","journal-title":"Fetal Medicine Foundation"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7549.1080"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_7_21_1","unstructured":"[cited 2016 18\/2\/2016];http:\/\/www.gestation.net\/growthcharts.htm]."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-985X.00122"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"issue":"3","key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/07350015.1988.10509663","article-title":"Missing\u2010data adjustments in large surveys","volume":"6","author":"Little RJA","year":"1988","journal-title":"J Bus Econ Stat"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"e_1_2_7_26_1","unstructured":"StataCorp.Stata statistical software: Release 14. College Station TX: StataCorp LP; 2015."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381803"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.78"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den389"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T05:41:37Z","timestamp":1719207697000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,16]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/pd.5069"],"URL":"https:\/\/doi.org\/10.1002\/pd.5069","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,16]]}}}