{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:12Z","timestamp":1740104832278,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to assess variation in detection and false positive rates and adverse pregnancy outcomes across different age groups when a one\u2010size\u2010fits\u2010all risk\u2010cutoff value, such as 1\/270, is used in integrated screening for Down syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A Monte Carlo simulation was utilized to estimate the detection and false positive rates as well as adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using a one\u2010size\u2010fits\u2010all risk\u2010cutoff value, such as 1\/270, can result in considerably high variations in detection and false positive rates across maternal ages and lead to a higher than the minimum possible total number of adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that the one\u2010size\u2010fits\u2010all risk\u2010cutoff value of 1\/270, commonly used in DS screening, should be revisited and alternative (possibly age\u2010based) cutoff values and strategies should be considered. \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5101","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T19:52:38Z","timestamp":1498593158000},"page":"894-898","source":"Crossref","is-referenced-by-count":1,"title":["Age\u2010based differences in the predictive accuracy of a one\u2010size\u2010fits\u2010all risk\u2010cutoff value in prenatal integrated screening for Down syndrome"],"prefix":"10.1002","volume":"37","author":[{"given":"Jia","family":"Yan","sequence":"first","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8720-0280","authenticated-orcid":false,"given":"Turgay","family":"Ayer","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Keskinocak","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Caughey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oregon Health &amp; Science University  Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001051"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000263470.89007.e3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200701000-00054"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4581"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4225"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00969-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.892"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199908)19:8<711::AID-PD614>3.0.CO;2-V"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1258\/096914105775220679"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00244.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1137-6"},{"key":"e_1_2_7_13_1","first-page":"1","article-title":"The introduction of the absolute risk for the detection of fetal aneuploidies in the first\u2010trimester screening","author":"Padula F","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2157"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1498"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta7110"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780192628268.003.0002"},{"key":"e_1_2_7_18_1","unstructured":"Centers for Disease Control and Prevention.National Center for Health Statistics. 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