{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:30:07Z","timestamp":1775244607074,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Determine prenatal detection rate, mortality and association with genetic abnormalities in patients with severe CHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Single center retrospective study in patients with severe CHD diagnosed prenatally or postnatally (2006 to 2014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 567 patients were included, 176 (31%) after prenatal diagnosis, with large differences in prenatal detection rate among CHD types. Coarctation (24%), tetralogy of Fallot (21%) and univentricular heart (19%) were the most prevalent CHD. Overall mortality rate was 30% with important contributions of prenatal mortality including termination of pregnancy (40%) and postnatal compassionate care (15%). In the group requiring surgery, mortality rate was 12%. Genetic testing was available in 70%. A genetic cause was present in 140\/394 patients tested (36%; 25% in the total group). Mortality was higher in the group with abnormal genetic testing compared with those with normal or no genetic testing (57\/141 vs 112\/423; <jats:italic>p<\/jats:italic>\u00a0=\u00a00,002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only one third of severe CHD are detected; overall mortality remains high (30%) with major contributions of termination of pregnancy and compassionate care. A genetic cause was found in 36% and was associated with a decreased survival. Counseling must include the possibility of associated genetic pathology and its impact on survival. \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5117","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T18:32:39Z","timestamp":1500575559000},"page":"983-991","source":"Crossref","is-referenced-by-count":21,"title":["Outcome after prenatal and postnatal diagnosis of complex congenital heart defects and the influence of genetic anomalies"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-2437","authenticated-orcid":false,"given":"Katya","family":"De Groote","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Paediatric Cardiology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Vanhie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Roets","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Prenatal Diagnosis Centre Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Ramaekers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Prenatal Diagnosis Centre Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"De Wilde","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Paediatric Cardiology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Panzer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Paediatric Cardiology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristof","family":"Vandekerckhove","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Paediatric Cardiology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Bove","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrien","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Van Herck","sequence":"additional","affiliation":[{"name":"Department of Public Health Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00ebl","family":"De Wolf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Paediatric Cardiology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.958405"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.05.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.008396"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.947002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2015.45.5.357"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36193"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-81"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.10.798"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12497"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-56"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.7.916"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.1.67"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.9.1269"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.03.065"},{"key":"e_1_2_6_18_1","unstructured":"GyselaersW JonckheerP AhmadzaiN et al.Welke onderzoeken zijn aanbevolen bij een zwangerschap? \u2013 Synthese. Good Clinical Practice (GCP) Brussel: Federaal Kenniscentrum voor de Gezondheidszorg (KCE).2015. KCE Reports 248As:1\u201342. D\/2015\/10 273\/55 [Internet]. 2015."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12403"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104001234"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2015.01.001"},{"issue":"9186","key":"e_1_2_6_22_1","first-page":"1242","article-title":"Current and potential impact of fetal diagnosis on prevalence and spectrum of serious congenital heart disease at term in the UK","volume":"354","author":"Bull C","year":"1999","journal-title":"British Paediatric Cardiac Association Lancet"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.206623"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802483106"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30123"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00172-1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104003099"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.05.044"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-23"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4525"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024068"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4912"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4452"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340310791162703"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4954"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:51:49Z","timestamp":1696002709000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,4]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/pd.5117"],"URL":"https:\/\/doi.org\/10.1002\/pd.5117","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,4]]}}}