{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:36Z","timestamp":1786978356063,"version":"build-2736575974"},"reference-count":116,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,10,22]],"date-time":"2017-10-22T00:00:00Z","timestamp":1508630400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of the study is to compare outcomes of ultrasound\u2010guided aspiration of fetal ovarian cysts with conservative management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic review of MEDLINE and Web of Science included studies reporting outcomes (prenatal and postnatal torsion, spontaneous resolution and surgery) of fetuses with ovarian cysts. Subgroup analysis was performed according to cyst diameter at diagnosis and cysts \u226540\u00a0mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010two non\u2010randomised studies reported on 380 cysts (324 observed and 56 aspirated\n                      <jats:italic>in utero<\/jats:italic>\n                      ) in 365 fetuses. All studies were case reports or series with high heterogeneity and risk of bias. The overall spontaneous resolution rate of conservatively managed cysts was 46%, yet decreased with increasing cyst size. Risk of prenatal ovarian torsion in conservatively managed cases depended on cyst size and was particularly important in the range 30 to 59\u00a0mm (15\u201334%). The rate of prenatal torsion in simple cysts \u226540\u00a0mm was lower in aspirated than conservatively managed cysts (0% vs 10%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). Aspirated cysts had lower rates of postnatal surgery (7%) compared with conservatively managed cysts (49%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cysts 30 to 59\u00a0mm were at highest risk of torsion. Simple cysts &gt;40\u00a0mm had lower rates of torsion when aspirated prenatally. Randomised studies and safety data are needed prior to routine prenatal ovarian cyst aspiration. \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.5143","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T13:56:45Z","timestamp":1504879005000},"page":"951-958","source":"Crossref","is-referenced-by-count":45,"title":["A systematic review and meta\u2010analysis on fetal ovarian cysts: impact of size, appearance and prenatal aspiration"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-5325","authenticated-orcid":false,"given":"Athanasios","family":"Tyraskis","sequence":"first","affiliation":[{"name":"Stem Cells and Regenerative Medicine UCL Institute of Child Health and Great Ormond Street Hospital  London 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