{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:37:20Z","timestamp":1775734640646,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T00:00:00Z","timestamp":1508025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To perform a systematic review examining the risk of chromosomal aberrations in apparently isolated intrauterine growth restriction (IUGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Search was conducted by research librarian in 5 databases. By independent screening of 2894 references, 2 investigators selected original studies examining the risk of chromosomal aberrations in apparently isolated IUGR diagnosed at the second and third trimesters by using ultrasound. We excluded studies describing IUGR combined with additional fetal anomalies detected by ultrasound and those where fetuses with structural anomalies or aneuploidy were not reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen observational cohort studies were found, encompassing 874 apparently isolated IUGR cases. Mean rate of chromosomal aberrations was 6.4%, ranging between 0% (in 3 studies) and 26.3%. Only 2 articles examined apparently isolated IUGR diagnosed in the third trimester, encompassing a total of 32 pregnancies. Invasive testing of these cases yielded normal karyotypes. A single article analyzed 137\u00a0second trimester IUGR pregnancies, reporting 2 abnormal karyotypes of minimal clinical significance. Overall quality of existing evidence was defined as \u201cvery low.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Due to a limited number of cases and insufficient quality of evidence, high\u2010quality well standardized case\u2010controlled trials should be conducted, further exploring the risk for chromosomal aberrations in pregnancies with isolated IUGR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5160","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T11:17:17Z","timestamp":1506338237000},"page":"1061-1066","source":"Crossref","is-referenced-by-count":25,"title":["Risk for chromosomal aberrations in apparently isolated intrauterine growth restriction: A systematic review"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-2130","authenticated-orcid":false,"given":"Lena","family":"Sagi\u2010Dain","sequence":"first","affiliation":[{"name":"Genetics Institute Carmel Medical Center  Haifa Israel"},{"name":"Department of Obstetrics and Gynecology Carmel Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Peleg","sequence":"additional","affiliation":[{"name":"Genetics Institute Carmel Medical Center  Haifa Israel"},{"name":"Department of Obstetrics and Gynecology Carmel Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomi","family":"Sagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bnai Zion Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2330-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000429658.85846.f9"},{"key":"e_1_2_7_4_1","unstructured":"(RCOG).RCoOaG. The investigation and management of the small\u2010for\u2010gestational\u2010age fetus. London (UK): Royal College of Obstetricians and Gynaecologists (RCOG) (Green\u2010top guideline; no 31).2013."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zefq.2012.06.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320440511"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92240-G"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1993.03050334.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90491-Z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140207"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1996.tb00990.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00292-9"},{"issue":"1","key":"e_1_2_7_15_1","first-page":"16","article-title":"[Analysis of chromosomal karyotypes in 300 fetal blood samples during the second and third trimesters of gestation]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi =","volume":"17","author":"Fang Q","year":"2000","journal-title":"Chin J Med Genet"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115123"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.715"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2298\/VSP0803195P"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330373"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2861"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2014.07.002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-209"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30274"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35410"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35837"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000000116"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30664-2"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.094367"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001405"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025273"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:58:00Z","timestamp":1696003080000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,15]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/pd.5160"],"URL":"https:\/\/doi.org\/10.1002\/pd.5160","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,15]]}}}