{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:59:13Z","timestamp":1784015953145,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO. 81571447"],"award-info":[{"award-number":["NO. 81571447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to investigate the significance of prenatal diagnosis of subependymal cysts (SEC). Diagnoses were made by brain ultrasonography (bUS) and confirmed by fetal brain magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed all the cases of isolated SEC diagnosed antenatally in our center from January 1, 2014, to December 31, 2015, and confirmed by fetal MRI. We followed up their evolution throughout pregnancy and the neonatal neurodevelopment at 3, 6, and 12\u00a0months using the Gesell Developmental Schedule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 91 cases in the cohort, 74 were bilateral and 17 unilateral. The SEC were significantly smaller in unilateral than bilateral cases (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Among the 35 cases with repeated bUS, SEC remained stable or decreased in size with advancing gestational age in 86% of cases. After excluding terminations of pregnancy (<jats:italic>n<\/jats:italic>\u00a0=\u00a013), neurodevelopment was normal in 75\/78 (96%) cases with developmental quotient \u226785.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Isolated SEC are usually a benign finding. Accurate diagnosis is important to differentiate SEC from other pathologic brain conditions with a combination of brain ultrasonography and MRI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5177","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T09:12:33Z","timestamp":1510045953000},"page":"1322-1326","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal diagnosis and prognosis of isolated subependymal cysts: A retrospective cohort study"],"prefix":"10.1002","volume":"37","author":[{"given":"Mengmeng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics Women's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Women's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Women's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Women's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-9781","authenticated-orcid":false,"given":"Qiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Women's Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.155028"},{"key":"e_1_2_7_3_1","first-page":"178","article-title":"Congenital subependymal pseudocysts: own data and meta\u2010analysis of the literature","volume":"3","author":"Makhoul IR","year":"2001","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00840.x"},{"key":"e_1_2_7_5_1","first-page":"28","article-title":"Fetal cytomegalovirus infection of the brain: the spectrum of sonographic findings","volume":"24","author":"Malinger G","year":"2003","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02011609"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.4.8141023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.85.3.F187"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807301924"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00848.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069372"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346571"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071295"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00595915"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14820"},{"issue":"5","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2223\/JPED.880","article-title":"Diagnosis of subependymal cysts by brain ultrasound","volume":"78","author":"Fekete SM","year":"2002","journal-title":"J Pediatr (Rio J)"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4916"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303223"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.02.009"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T19:56:42Z","timestamp":1696017402000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":18,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/pd.5177"],"URL":"https:\/\/doi.org\/10.1002\/pd.5177","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}