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The high detection rate of clinically significant CNVs was evident in fetuses with cerebellar hypoplasia (54.6%, 6\/11), vermis hypoplasia (33.3%, 1\/3), and Dandy\u2010Walker malformation (25.0%, 3\/12). Compare with fetuses without other anomalies, cases with CH and additional malformations had the higher CMA detection rate (33.3% vs 88.9%). Three cases of isolated unilateral CH with intact vermis and normal CMA result had normal outcomes. The deletion of 5p15, 6q terminal deletion, and X chromosome aberrations were the most frequent genetic defects associated with cerebellar hypoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among fetuses with PFA, those with cerebellar hypoplasia, vermis hypoplasia, or Dandy\u2010Walker malformation are at the highest risk of clinically significant CNVs. Chromosomal microarray analysis revealed the most frequent chromosomal aberrations associated with CH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5190","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T03:46:41Z","timestamp":1511495201000},"page":"91-98","source":"Crossref","is-referenced-by-count":24,"title":["Prenatal diagnosis of posterior fossa anomalies: Additional value of chromosomal microarray analysis in fetuses with cerebellar hypoplasia"],"prefix":"10.1002","volume":"38","author":[{"given":"Zhiyong","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou 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