{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:39:19Z","timestamp":1767109159132,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to focus on fetuses diagnosed with severe hydronephrosis and correlate prenatal sonographic characteristics with postnatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases presenting prenatally with severe hydronephrosis (anterior\u2010posterior renal pelvic diameter &gt;15\u00a0mm) were collected retrospectively over a period of 11\u00a0years and divided into 2 groups: (1) isolated hydronephrosis and (2) those associated with congenital anomalies of the kidney and urinary tract (CAKUT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 83 fetuses comprised the study group: 35 fetuses had isolated severe hydronephrosis and 48 had associated CAKUT. The mean anterior\u2010posterior renal pelvic diameter was 22.6\u00a0\u00b1\u00a08.5\u00a0mm (range 15.0\u201066.0\u00a0mm).<\/jats:p><jats:p>The CAKUT group was associated with a significantly increased incidence of postnatal need for surgery (17.6% vs 44.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.014), dysplastic kidney (0% vs 14%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.023), and total abnormal outcome (52.9% vs 86%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) in comparison with isolated severe prenatal hydronephrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe fetal hydronephrosis has a wide postnatal clinical spectrum, which is mainly influenced by the presence of associated sonographic CAKUT findings. These clinical data have biological relevance: a genetic or environmental defect that influences multiple renal developmental processes leads to hydronephrosis but also to concomitant malformations (CAKUT) and critically influences renal prognosis. A more selective abnormal developmental process that results in isolated enlarged pelvis even to a severe extent has less influence on renal prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5206","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T22:24:38Z","timestamp":1515536678000},"page":"179-183","source":"Crossref","is-referenced-by-count":8,"title":["Severe fetal hydronephrosis: the added value of associated congenital anomalies of the kidneys and urinary tract (<scp>CAKUT<\/scp>) in the prediction of postnatal outcome"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-0679","authenticated-orcid":false,"given":"Sharon","family":"Perlman","sequence":"first","affiliation":[{"name":"Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Roitman","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Lotan","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Division of Pediatric Nephrology, Edmond and Lily Children's Hospital Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Kivilevitch","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Pode\u2010Shakked","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Division of Pediatric Nephrology, Edmond and Lily Children's Hospital Sheba Medical Center  Tel Hashomer Israel"},{"name":"Pediatric Stem Cell Research Institute, Edmond and Lily Children's Hospital Sheba Medical Center  Tel Hashomer Israel"},{"name":"Department of Pediatrics A, Edmond and Lily Children's Hospital Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Pode\u2010Shakked","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"The Dr. Pinchas Borenstein Talpiot Medical Leadership Program Sheba Medical Center  Tel Hashomer Israel"},{"name":"The Danek Gertner Institute of Human Genetics Sheba Medical Center  Tel Hashomer 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