{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:26:46Z","timestamp":1740104806093,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangzhou Science Technology and Innovation Commission","award":["201607010341"],"award-info":[{"award-number":["201607010341"]}]},{"name":"Science and Technology Department of Guangdong Province","award":["2016A020218003","2017A020214010"],"award-info":[{"award-number":["2016A020218003","2017A020214010"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>What's already known about this topic?\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The double bubble sign is strongly indicative of duodenal obstruction.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Patients with duodenal obstruction are high risk of other anomalies, especially trisomy 21.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p>What does this study add?\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>A much <jats:italic>lower percentage of<\/jats:italic> associated malformations in fetuses with double bubble was found.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>No other chromosomal anomalies or submicroscopic pathogenic aberrations excepting trisomy 21 were found in fetuses with double bubble.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Noninvasive prenatal testing may be recommended for genetic evaluation of the etiology of fetal double 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