{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:57:16Z","timestamp":1787684236392,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T00:00:00Z","timestamp":1523750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate cardiac function by conventional echocardiography and tissue Doppler imaging in fetuses with left congenital diaphragmatic hernia (CDH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Conventional echocardiography (myocardial performance index, ventricular filling velocities, and E\/A ratios) and tissue Doppler imaging (annular myocardial peak velocities, E\/E\u2032 and E\u2032\/A\u2032 ratios) in mitral, septal, and tricuspid annulus were evaluated in a cohort of 31 left\u2010sided CDH fetuses and compared with 75 controls matched for gestational age 2:1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison to controls, CDH fetuses had prolonged isovolumetric time periods (isovolumetric contraction time 35\u00a0ms vs 28\u00a0ms, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), with higher myocardial performance index (0.49 vs 0.42, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and tricuspid E\/A ratios (0.77 vs 0.72, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.033). Longitudinal function assessed by tissue Doppler showed signs of impaired relaxation (mitral lateral A\u2032 8.0 vs 10.1\u00a0cm\/s, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and an increased mitral lateral E\u2032\/A\u2032 ratio 0.93 vs 0.78, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) in the CDH fetuses as compared with controls, with preserved systolic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Left CDH fetuses show echocardiographic signs of diastolic dysfunction, probably secondary to fetal heart compression, maintaining a preserved systolic function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5253","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T01:04:05Z","timestamp":1521853445000},"page":"422-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Characterizing cardiac dysfunction in fetuses with left congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-3578","authenticated-orcid":false,"given":"M\u00f3nica","family":"Cruz\u2010Lemini","sequence":"first","affiliation":[{"name":"Fetal Medicine Mexico, Fetal Surgery Research Unit, Children and Women's Specialty Hospital; Unidad de Investigaci\u00f3n en Neurodesarrollo Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Campus Juriquilla  Juriquilla Queretaro Mexico"},{"name":"BCNatal\u2010Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Universitat de Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Valenzuela\u2010Alcaraz","sequence":"additional","affiliation":[{"name":"BCNatal\u2010Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Universitat de Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Granados\u2010Montiel","sequence":"additional","affiliation":[{"name":"Tissue Engineering, Cell Therapy and Regenerative Medicine Research Unit Instituto Nacional de Rehabilitaci\u00f3n  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"BCNatal\u2010Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Universitat de Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Crispi","sequence":"additional","affiliation":[{"name":"BCNatal\u2010Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Universitat de Barcelona and Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Gratac\u00f3s","sequence":"additional","affiliation":[{"name":"BCNatal\u2010Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de Deu), Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Universitat 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