{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:19:07Z","timestamp":1790813947875,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["ERNICA funding"],"award-info":[{"award-number":["ERNICA funding"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Congenital diaphragmatic hernia is a rare disease associated with high mortality and morbidity. Antenatal ultrasound screening identifies more than 70% of cases, providing the opportunity for in utero referral to a tertiary care center for expert assessment and perinatal management. Additional genetic and morphologic assessment may be used to rule out associated anomalies. In isolated cases, the outcome may be predicted prenatally by medical imaging. The combination of lung size and liver herniation is a widely accepted method to stratify fetuses into groups with an increasing degree of pulmonary hypoplasia and corresponding mortality rates. Ultrasound measurement of the observed to expected lung\u2010to\u2010head ratio (o\/e LHR) is most widely used. The o\/e LHR is an independent predictor of survival and short\u2010term morbidity. Finally, evaluation of stomach position has recently been introduced as an indirect method to estimate severity of the disease in left\u2010sided defects, as it has been shown to correlate with the proportion of intrathoracic liver. Herein, we propose a protocol for the standardized ultrasound assessment of fetuses with isolated CDH and individualized prediction of neonatal outcome.<\/jats:p>","DOI":"10.1002\/pd.5297","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T13:48:00Z","timestamp":1529502480000},"page":"629-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Proposal for standardized prenatal ultrasound assessment of the fetus with congenital diaphragmatic hernia by the\n                    <scp>European<\/scp>\n                    reference network on rare inherited and congenital anomalies (ERNICA)"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5029-7899","authenticated-orcid":false,"given":"Francesca Maria","family":"Russo","sequence":"first","affiliation":[{"name":"Clinical Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"Academic Department of Development and Regeneration, Cluster Woman and Child KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Gael","family":"Cordier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00f4pital Antoine B\u00e9cl\u00e8re, AP\u2010HP, Universit\u00e9 Paris Sud  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"De Catte","sequence":"additional","affiliation":[{"name":"Clinical Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"Academic Department of Development and Regeneration, Cluster Woman and Child KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Saada","sequence":"additional","affiliation":[{"name":"Centre R\u00e9f\u00e9rence Maladie Rare: Hernie de Coupole Diaphragmatique  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-0765","authenticated-orcid":false,"given":"Alexandra","family":"Benachi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00f4pital Antoine B\u00e9cl\u00e8re, AP\u2010HP, Universit\u00e9 Paris Sud  Clamart France"},{"name":"Centre R\u00e9f\u00e9rence Maladie Rare: Hernie de Coupole Diaphragmatique  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[{"name":"Clinical Department of Obstetrics and Gynaecology University Hospitals Leuven  Leuven Belgium"},{"name":"Academic Department of Development and Regeneration, Cluster Woman and Child KU Leuven  Leuven Belgium"},{"name":"Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Workstream Prenatal Management, ERNICA European reference network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-3-201302050-00583"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)92878-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30201-X"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-9485-8_20"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.076"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.08.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2839"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320605"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.09.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90338-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4052"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11212"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.10.031"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90471-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12092"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.031"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10095"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11065"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2651"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(05)80163-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199811)18:11<1138::AID-PD416>3.0.CO;2-A"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6146"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13065"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.166.5.8615269"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1995.14.7.515"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90524-3"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.906576"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8892"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440649"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14759"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.11.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30131"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90099-9"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.73.868.10844860"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.125004"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(84)80105-0"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.12.006"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.5.1106"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10097"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3958"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3680"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.1.r01ap18236"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5168"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2618"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2413051228"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2709-6"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101135"},{"key":"e_1_2_11_49_1","volume-title":"GeneReviews (R)","author":"Pober BR","year":"1993"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1086\/513442"},{"issue":"1","key":"e_1_2_11_51_1","first-page":"75","article-title":"Where to look for the genes related to diaphragmatic hernia?","volume":"14","author":"Lurie IW","year":"2003","journal-title":"Genet Couns"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35722"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199812)18:12<1289::AID-PD432>3.0.CO;2-Y"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33660"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201652"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33410"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2011.089680"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-2"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010801)102:2<161::AID-AJMG1453>3.0.CO;2-O"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980923)79:3<215::AID-AJMG13>3.0.CO;2-K"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000103)90:1<45::AID-AJMG9>3.0.CO;2-O"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30125"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20381"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.27.6.403"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.116410"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2014.04.012"},{"key":"e_1_2_11_67_1","doi-asserted-by":"crossref","unstructured":"KardonG AckermanKG.Congenital diaphragmatic hernias: from genes to mechanisms to therapies.2017;10(8):955\u2010970.","DOI":"10.1242\/dmm.028365"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7577"},{"key":"e_1_2_11_69_1","doi-asserted-by":"crossref","unstructured":"DoneE GucciardoL Van MieghemT.Clinically relevant discordances identified after tertiary reassessment of fetuses with isolated congenital diaphragmatic hernia.2017;37(9):883\u2010888.","DOI":"10.1002\/pd.5060"},{"key":"e_1_2_11_70_1","article-title":"Prognosis of isolated congenital diaphragmatic hernia using lung\u2010to\u2010head circumference ratio: variability across centers in a national perinatal network","volume":"2017","author":"Senat MV","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.5297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.5297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T18:13:05Z","timestamp":1694974385000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.5297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,23]]},"references-count":69,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/pd.5297"],"URL":"https:\/\/doi.org\/10.1002\/pd.5297","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,23]]},"assertion":[{"value":"2018-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}