{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:25:05Z","timestamp":1772108705558,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate neonatal mortality and morbidity up to 6\u00a0months in neonates with congenital diaphragmatic hernia (CDH) with or without a hernia sac.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010two cases of isolated CDH were included in a retrospective single\u2010center study between January 2010 and December 2016. Hernia sac was defined at the time of surgery or at postmortem examination if the neonate died before surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen newborns (23.6%) had a hernia sac. Survival at 6\u00a0months was significantly greater for isolated CDH with a hernia sac: 100% versus 63.6% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003). High\u2010frequency oscillatory ventilation was used significantly more in the no hernia sac group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). At surgery, the need for patch repair was significantly lower in the hernia sac group: 12% versus 50% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). The prenatal observed\/expected lung\u2010to\u2010head ratio was significantly higher in the hernia sac group than in the no hernia sac group: 49.7% versus 38.6% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of a hernia sac in CDH is associated with better outcome, especially survival at 6\u00a0months. If the presence of a hernia sac is recognized as a particular entity, which carries a good prognosis, it is necessary to be able to diagnose it prenatally, especially in the era of prenatal fetal surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5326","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T05:18:58Z","timestamp":1530249538000},"page":"638-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Congenital diaphragmatic hernia has a better prognosis when associated with a hernia sac"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-2815","authenticated-orcid":false,"given":"Hanane","family":"Bouchghoul","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics H\u00f4pital Bic\u00eatre  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Reference Center for Rare Disease: Congenital Diaphragmatic Hernia  Clamart France"},{"name":"UFR M\u00e9decine Universit\u00e9 Paris Sud  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriane","family":"Marty","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics H\u00f4pital Bic\u00eatre  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Reference Center for Rare Disease: Congenital Diaphragmatic Hernia  Clamart France"},{"name":"UFR M\u00e9decine Universit\u00e9 Paris Sud  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Fouquet","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Disease: Congenital Diaphragmatic Hernia  Clamart France"},{"name":"Department of Pediatric Surgery H\u00f4pital Bic\u00eatre  Le Kremlin\u2010Bic\u00eatre 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