{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:59:49Z","timestamp":1793177989006,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012023","name":"Sanquin Blood Supply Foundation","doi-asserted-by":"crossref","award":["L2181"],"award-info":[{"award-number":["L2181"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we aim to evaluate trends in the condition of fetuses and neonates with hemolytic disease at the time of first intrauterine transfusion (IUT) and at birth, in relation to routine first\u2010trimester antibody screening, referral guidelines, and centralization of fetal therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted a 30\u2010year cohort study including all women and fetuses treated with IUT for red cell alloimmunization at the Dutch national referral center for fetal therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six hundred forty\u2010five fetuses received 1852 transfusions between 1 January 1987 and 31 December 2016. After the introduction of routine first\u2010trimester antibody screening, the hydrops rate declined from 39% to 15% (OR 0.284, 95% CI, 0.19\u20100.42,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In the last time cohort, only one fetus presented with severe hydrops (OR 0.482, 95% CI, 0.38\u20100.62,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Infants are born less often &lt;32\u00a0weeks (OR 0.572, 95% CI, 0.39\u20100.83,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004) and with higher neonatal hemoglobin (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Neonatal hemoglobin was positively independently associated with gestational age at birth, fetal hemoglobin, and additional intraperitoneal transfusion at last IUT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe alloimmune hydrops, a formerly often lethal condition, has practically disappeared, most likely as a result of the introduction of routine early alloantibody screening, use of national guidelines, and pooling of expertise in national reference laboratories and a referral center for fetal therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.5355","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T07:34:42Z","timestamp":1536219282000},"page":"943-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["The near disappearance of fetal hydrops in relation to current state\u2010of\u2010the\u2010art management of red cell alloimmunization"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-6142","authenticated-orcid":false,"given":"Carolien","family":"Zwiers","sequence":"first","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J.","family":"Klumper","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masja","family":"de Haas","sequence":"additional","affiliation":[{"name":"Center for Clinical Transfusion Research, Sanquin Research  Leiden The Netherlands"},{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Center  Leiden The Netherlands"},{"name":"Immunohematology Diagnostic Services, Sanquin Blood Supply  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge L.","family":"van Kamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12265"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6313.373"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.116690"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.09.024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1990.tb00855.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17319"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01760.x"},{"key":"e_1_2_10_9_1","unstructured":"van derPloegCPB Sch\u00f6nbeckY OomenP VosK.Prenatale Screening Infectieziekten en Erytrocytenimmunisatie (PSIE). 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