{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:41:42Z","timestamp":1780047702529,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aims to evaluate the predictive value of first trimester placental volume in pregnancies destined to develop fetal growth restriction (FGR) and preeclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective observational study including placentas from 34 FGR, 12 PE, 15 GH (gestational hypertension) pregnancies, and 265 controls. Placental volume (PV) was obtained using VOCAL technique, and a <jats:italic>z<\/jats:italic> score was calculated (<jats:italic>z<\/jats:italic>\u2010PV). The association of PV with other first trimester variables and maternal characteristics was assessed with Spearman's correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PV increased exponentially with crown\u2010rump length (CRL) and was unrelated to maternal factors (weight, age, parity, and smoking status) as well as first trimester uterine artery Doppler, free \u03b2\u2010hCG, nuchal translucency, or fetal heart rate. However, PV was positively associated with maternal height, CRL, PAPP\u2010A, and birth weight. <jats:italic>z<\/jats:italic>\u2010PV was a strong predictor for FGR with abnormal fetal Dopplers (AUC\u00a0=\u00a00.9472, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:italic>z<\/jats:italic>\u2010PV provided moderate prediction of FGR with normal fetal Dopplers (AUC\u00a0=\u00a00.8396, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), PE (AUC\u00a0=\u00a00.8312, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and GH (AUC\u00a0=\u00a00.7640, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The addition of maternal weight, PAPP\u2010A, \u03b2\u2010hCG, and uterine artery Doppler improved our models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At 11 to 14\u00a0weeks, PV is an independent predictor of pregnancy complications related to placental insufficiency, and the predictive ability is greater for FGR pregnancies with abnormal fetal Dopplers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5356","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T14:54:56Z","timestamp":1536245696000},"page":"928-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Placental volume at 11 to 14 gestational weeks in pregnancies complicated with fetal growth restriction and preeclampsia"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1435","authenticated-orcid":false,"given":"Ioannis","family":"Papastefanou","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology, Athens Medical School National and Kapodistrian University of Athens, 'Attikon' University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalambos","family":"Chrelias","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology, Athens Medical School National and Kapodistrian University of Athens, 'Attikon' University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalambos","family":"Siristatidis","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology, Athens Medical School National and Kapodistrian University of Athens, 'Attikon' University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1141-4738","authenticated-orcid":false,"given":"Dimitra","family":"Kappou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makarios","family":"Eleftheriades","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Gynecology University of Athens Medical School, Aretaieio Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Kassanos","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, 3rd Department of Obstetrics and Gynaecology, Athens Medical School National and Kapodistrian University of Athens, 'Attikon' University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341712"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.11.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4754"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324318"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2641"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6455"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.01.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3162-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.11.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.08.015"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12366"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4161"},{"key":"e_1_2_7_15_1","first-page":"159","article-title":"Diagnosis and management of preeclampsia and eclampsia. 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