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challenging.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p>What does this study add?\n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Intrauterine growth restriction and very low PAPP\u2010A levels with or without first\u2010trimester risk &lt;1\/250 and, a fortiori, association with placental abnormalities should be indicators for chorionic villus sampling.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cases should be closely monitored with serial ultrasounds for fetal growth and Doppler flows, FHR and maternal arterial pressure.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/pd.5357","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T02:44:47Z","timestamp":1536547487000},"page":"924-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pregnancy course and outcomes in mosaic trisomy 16 confined to the placenta: A case 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