{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:11:55Z","timestamp":1780636315320,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1021252"],"award-info":[{"award-number":["1021252"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1105603"],"award-info":[{"award-number":["1105603"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the impact of non\u2010invasive prenatal testing (NIPT) on trends in the prenatal diagnosis of sex chromosome aneuploidy (SCA) in a population with &gt;73,000 annual births.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective population\u2010based cohort study from 1986\u20132016 of all women undergoing prenatal diagnosis before 25\u00a0weeks gestation in the Australian state of Victoria. Statistical significance was tested using the chi\u2010square test for trend or proportions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 2,043,345 births and 842 SCA diagnoses from 1986\u20132016. The percentage of prenatal diagnostic tests leading to a SCA diagnosis increased significantly from 0.95% in 2010 to 2.93% in 2016 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) but due to a concurrent decline in testing, the annual prenatal diagnosis rate of SCA remained stable at 4.4\/10,000 births. Among confirmed fetal SCAs the most common indication for testing in 1986 was advanced maternal age (63%); in 2016 it was high risk NIPT (49%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SCAs now make up an increasing proportion of prenatal diagnostic results but due to the overall decline in diagnostic testing, the prenatal prevalence as a percentage of births remained steady. The ascertainment of fetal SCA has evolved from an incidental finding after testing for increased risk of trisomy 21, to a diagnosis obtained after suspected SCA on NIPT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.5363","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T01:48:51Z","timestamp":1537926531000},"page":"1062-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Population\u2010based trends in the prenatal diagnosis of sex chromosome aneuploidy before and after non\u2010invasive prenatal testing"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-2183","authenticated-orcid":false,"given":"Allanah","family":"Howard\u2010Bath","sequence":"first","affiliation":[{"name":"Murdoch Children's Research Institute, Public Health Genetics Group  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-9035","authenticated-orcid":false,"given":"Alice","family":"Poulton","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute, Public Health Genetics Group  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Halliday","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute, Public Health Genetics Group  Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-3562","authenticated-orcid":false,"given":"Lisa","family":"Hui","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute, Public Health Genetics Group  Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Heidelberg Victoria Australia"},{"name":"Mercy Hospital for Women, Department of Perinatal Medicine  Heidelberg Victoria Australia"},{"name":"The Northern Hospital, Department of Obstetrics and Gynaecology  Epping Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.78"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.042"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.635730"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355407"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4127"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-42"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213097"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3975"},{"key":"e_1_2_10_12_1","volume-title":"Principles and practice of screening for disease. 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